You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) Antibodies

The protein encoded by RASGRP2 is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. Additionally we are shipping RASGRP2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RASGRP2 10235 Q7LDG7
RASGRP2 361714 P0C643
RASGRP2 19395 Q9QUG9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-RASGRP2 Antibodies at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RASGRP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of RASGRP2 Antibody (N-term) Cat.-No AP53590PU-N with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue). Formalin fixed, paraffin embedded human brain tissue stained with RASGRP2 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB RASGRP2 Antibody (N-term) (ABIN656117) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged RASGRP2 is approximately 0.3ng/ml as a capture antibody. Western Blot analysis of RASGRP2 expression in transfected 293T cell line by RASGRP2 monoclonal antibody (M09), clone 3D8.Lane 1: RASGRP2 transfected lysate(75.5 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged RASGRP2 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (p), IP, WB   100 μL Log in to see 5 to 7 Days
$452.81
Details
Human Rabbit Un-conjugated IF, IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB RASGRP2 polyclonal antibody (A01), Lot # NIH47060208QCS1 Western Blot analysis of RASGRP2 expression in A-431 . Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details

RASGRP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
,
,
, , , , ,
Rat (Rattus)


Mouse (Murine)


Top referenced anti-RASGRP2 Antibodies

  1. Human Polyclonal RASGRP2 Primary Antibody for IF, IHC (p) - ABIN954463 : Nagamine, Matsuda, Hori: Identification of the gene regulatory region in human rasgrp2 gene in vascular endothelial cells. in Biological & pharmaceutical bulletin 2010 (PubMed)
    Show all 5 references for ABIN954463

  2. Cow (Bovine) Polyclonal RASGRP2 Primary Antibody for WB - ABIN2787843 : Katagiri, Shimonaka, Kinashi: Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. in The Journal of biological chemistry 2004 (PubMed)

  3. Human Monoclonal RASGRP2 Primary Antibody for ELISA, WB - ABIN523644 : Boudreaux, Catalfamo, Klok: Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. in Translational research : the journal of laboratory and clinical medicine 2007 (PubMed)

  4. Human Polyclonal RASGRP2 Primary Antibody for IF, IHC (p) - ABIN656117 : Eto, Murphy, Kerrigan, Bertoni, Stuhlmann, Nakano, Leavitt, Shattil: Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

More Antibodies against RASGRP2 Interaction Partners

Human RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

  1. Human CalDAG-GEFI (show RASGRP1 Antibodies) gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

  2. phosphorylation of CalDAG-GEFI (show RASGRP1 Antibodies) is a critical mechanism by which PKA controls Rap1b (show RAP1B Antibodies)-dependent platelet aggregation

  3. RasGRP2 increases cell viability and cell-matrix adhesion through increased Ras expression and Rap1 activation, respectively, in endothelial cells.

  4. NIH3T3 cells were found nonpermissive to mtHSV but they became permissive following transformation with the Rasgrp2 gene. This effect was linked to the activation of the Ras-PKR (show PKLR Antibodies) signaling pathway.

  5. analyzed the 5'-flanking region of rasgrp2 gene by a luciferase assay, which revealed that not only a promoter but also silencer regions were present upstream of D1E, suggesting rasgrp2 expression is controlled by a combination of promotion and repression

  6. CalDAG-GEFI (show RASGRP1 Antibodies) plays a role in inside-out signaling to alphaIIbbeta3

Cow (Bovine) RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

Mouse (Murine) RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

  1. (i) STIM1 (show STIM1 Antibodies)/SOCE is critical for procoagulant activity but not the proadhesive function of platelets; and (ii) at the site of vascular injury, STIM1 (show STIM1 Antibodies) and CalDAG-GEFI are critical for the first wave of thrombin (show F2 Antibodies) generation mediated by procoagulant platelets

  2. we evaluated the contribution of CalDAG-GEFI to platelet activation in a model of immune-mediated thrombocytopenia and thrombosis syndromes

  3. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 (show P2RY12 Antibodies) facilitates delayed but sustained integrin activation.

  4. CalDAG-GEFI helps regulate neutrophil chemotaxis, independent of its established role in integrin activation, through a mechanism that involves actin cytoskeleton and cellular polarization.

  5. In a brain-slice explant model of Huntington's disease, knock-down of CalDAG-GEFI expression rescues striatal neurons from pathology induced by transfection of polyglutamine-expanded Htt (show HTT Antibodies) exon 1.

  6. CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3

  7. CalDAG-GEFI regulated the activation of beta(1) and beta(3) integrins in platelets, and CalDAG-GEFI deficiency caused complete inhibition of arterial thrombus formation.

  8. CalDAG-GEFI and PKC (show PKC Antibodies) represent separate, but synergizing, pathways important for alphaIIbbeta3 activation in platelets activated through the PAR4 (show F2RL3 Antibodies) receptor.

RASGRP2 Antigen Profile

Protein Summary

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with RASGRP2

  • RAS guanyl releasing protein 2 (RASGRP2) antibody
  • RAS guanyl releasing protein 2 (calcium and DAG-regulated) (RASGRP2) antibody
  • RAS guanyl releasing protein 2 (calcium and DAG-regulated) (Rasgrp2) antibody
  • RAS, guanyl releasing protein 2 (Rasgrp2) antibody
  • CalDAG-GEFI antibody
  • Caldaggef1 antibody
  • CDC25L antibody
  • RASGRP2 antibody

Protein level used designations for RASGRP2

RAS guanyl releasing protein 2 , RAS guanyl releasing protein 2, isoform 3 , F25B3.3 kinase-like protein , RAS guanyl nucleotide-releasing protein 2 , RAS guanyl-releasing protein 2 , calcium and DAG-regulated guanine nucleotide exchange factor I , calcium and diacylglycerol-regulated guanine nucleotide exchange factor I , cdc25-like protein , guanine exchange factor MCG7 , hCDC25L , RAS, guanyl releasing protein 2 , calDAG-GEFI , calcium diacylglycerol guanine nucleotide exchange factor I , CalDAG-GEFI , F25B3.3 kinase like protein , RAP 1A protein-specific guanine nucleotide exchange factor 1 , RAS, guanyl releasing protein 2; RAP 1A protein-specific guanine nucleotide exchange factor 1; CalDAG-GEFI

GENE ID SPECIES
100137599 Papio anubis
10235 Homo sapiens
361714 Rattus norvegicus
512056 Bos taurus
100328903 Oryctolagus cuniculus
19395 Mus musculus
Selected quality suppliers for anti-RASGRP2 (RASGRP2) Antibodies
Did you look for something else?