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RASGRP2 antibody (C-Term)

RASGRP2 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5564284
  • Target See all RASGRP2 Antibodies
    RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))
    Binding Specificity
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 17
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 14
    • 3
    Rabbit
    Clonality
    • 15
    • 2
    Polyclonal
    Conjugate
    • 17
    This RASGRP2 antibody is un-conjugated
    Application
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    Recognizes human and mouse RasGRP2.
    Cross-Reactivity
    Human, Mouse (Murine)
    Purification
    Antigen affinity purified.
    Immunogen
    Synthetic peptide corresponding to a human RasGRP2 sequence located at the C-terminus of the RasGEF domain.
    Top Product
    Discover our top product RASGRP2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 2 mg/mL BSA and 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: +4°C
    Stable for at least 6 months after receipt when stored at +4°C.
    Expiry Date
    6 months
  • Target
    RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))
    Alternative Name
    RasGRP2 (RASGRP2 Products)
    Synonyms
    CALDAG-GEFI antibody, CDC25L antibody, xrasgrp2 antibody, RASGRP2 antibody, Caldaggef1 antibody, CalDAG-GEFI antibody, rasgrp2 antibody, RAS guanyl releasing protein 2 antibody, RAS guanyl releasing protein 2 (calcium and DAG-regulated) S homeolog antibody, RAS, guanyl releasing protein 2 antibody, RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog antibody, RASGRP2 antibody, rasgrp2.S antibody, Rasgrp2 antibody, rasgrp2.L antibody
    Background
    RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.
    UniProt
    Q7LDG7
    Pathways
    TCR Signaling
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