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anti-Ran GTPase Activating Protein 1 (RANGAP1) Antibodies

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. Additionally we are shipping Ran GTPase Activating Protein 1 Proteins (5) and Ran GTPase Activating Protein 1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RANGAP1 5905 P46060
RANGAP1 19387 P46061
RANGAP1 362965  
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Top anti-Ran GTPase Activating Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-RANGAP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of RANGAP1 (arrow) using rabbit polyclonal RANGA... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185170 staining (0.2µg/ml) of 3T3 lysate (RIPA buffer, 35µg total ... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Mouse Rabbit Un-conjugated ICC, IF, IHC (p), WB 0.1 mL Log in to see 5 to 6 Days
$429.10
Details
Cow Goat Un-conjugated EIA, IHC (p), WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Rabbit Un-conjugated WB AP19039PU-N RanGAP1 antibody staining of 293T (A) whole cell lysate (3... 0.1 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE a... IHC-P Image Immunohistochemical analysis of paraffin-embedded human Tr... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details

RANGAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Ran GTPase Activating Protein 1 Antibodies

  1. Mouse (Murine) RANGAP1 Primary Antibody for ICC, IF - ABIN1042672 : Xia, Lee, Altieri: Tumor cell dependence on Ran-GTP-directed mitosis. in Cancer research 2008 (PubMed)
    Show all 3 references for ABIN1042672

  2. Human Polyclonal RANGAP1 Primary Antibody for IHC (p), WB - ABIN657698 : Zhang, Sarge: Mel-18 interacts with RanGAP1 and inhibits its sumoylation. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for ABIN657698

  3. Human Polyclonal RANGAP1 Primary Antibody for WB - ABIN2786743 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007 (PubMed)

  4. Human Polyclonal RANGAP1 Primary Antibody for IHC, ELISA - ABIN185170 : Bischoff, Krebber, Kempf, Hermes, Ponstingl: Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)

More Antibodies against Ran GTPase Activating Protein 1 Interaction Partners

Human Ran GTPase Activating Protein 1 (RANGAP1) interaction partners

  1. our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC (show NPC1 Antibodies) localization of RanGAP1 is dependent on CRM1 (show XPO1 Antibodies)-mediated nuclear export.

  2. immune cell adaptor SLP-76 (show LCP2 Antibodies) binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) nuclear entry in T cells

  3. Differentiation of human coronary artery smooth muscle cell to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels.

  4. Determinants of small ubiquitin-like modifier 1 (SUMO1 (show SUMO1 Antibodies)) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin (show AGFG2 Antibodies) RanBP2 (show RANBP2 Antibodies).

  5. Analysis of the dynamics of E2(Ubc9 (show UBE2I Antibodies))-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2 (show RANBP2 Antibodies)) revealed that two different allosteric sites regulate the ligase activity.

  6. the RanGAP1 consensus sumoylation site and SUMO-1 (show SUMO1 Antibodies) C terminus are both conformationally flexible

  7. the 3.0-A crystal structure of a four-protein complex of Ubc9 (show UBE2I Antibodies), a Nup358/RanBP2 (show RANBP2 Antibodies) E3 ligase domain (IR1 (show NISCH Antibodies)-M) and SUMO-1 (show SUMO1 Antibodies) conjugated to the carboxy-terminal domain of RanGAP1

  8. RanGAP1 is phosphorylated on Ser (show SIGLEC1 Antibodies)-358 in vivo & in vitro. Phosphorylated RanGAP1, but not a mutant at 358S, formed a stable ternary complex with Ran and RanBP1 (show RANBP1 Antibodies) in vivo, suggesting that its 358S phosphorylation affects the Ran system.

  9. The results of this study strengthen the conclusion that mel-18 (show PCGF2 Antibodies) functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1.

Mouse (Murine) Ran GTPase Activating Protein 1 (RANGAP1) interaction partners

  1. nuclear localization of Ran was strongly increased in MYCBP2 (show MYCBP2 Antibodies)-deficient DRGs

  2. immune cell adaptor SLP-76 (show LCP2 Antibodies) binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) nuclear entry in T cells

  3. These data suggest a dual function of the Nup358 (show RANBP2 Antibodies)-RanGAP1 complex as a coordinator of importin beta (show KPNB1 Antibodies) recycling and reformation of novel import complexes.

  4. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.

Arabidopsis thaliana Ran GTPase Activating Protein 1 (RANGAP1) interaction partners

  1. The data show that plant development is differentially affected by RanGAP mutant allele combinations of increasing severity and requires the GAP activity of RanGAP, while the subcellular positioning of RanGAP is dispensable.

  2. AtRanGAP1 has a mitotic trafficking pattern uniquely different from that of vertebrate RanGAP.

  3. In a wip1-1/wip2-1/wip3-1 triple mutant, RanGAP1 is dislocated from the nuclear envelope in undifferentiated root-tip cells, whereas nuclear envelope targeting in differentiated root cells and targeting to the cell plate remain intact.

  4. Data suggest that an unanticipated complexity of RanGAP nuclear envelope targeting and at least one member of each NE-associated coiled-coil and transmembrane domains protein family is required for RanGAP targeting in root tip cells.

  5. propose that Arabidopsis RanGAP, a continuous positive protein marker of the plant division plane, has a role in spatial signaling during plant cell division

  6. These data suggest that both HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting; this may be the first described in planta activity for the WPP-domain proteins.

Ran GTPase Activating Protein 1 (RANGAP1) Antigen Profile

Protein Summary

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Gene names and symbols associated with RANGAP1

  • Ran GTPase activating protein 1 (RANGAP1) antibody
  • ran GTPase activating protein 1 (TERG_02084) antibody
  • Ran GTPase activating protein 1 (rangap1-b) antibody
  • RAN GTPase activating protein 1 (Rangap1) antibody
  • chondroadherin-like (CHADL) antibody
  • Ran GTPase activating protein 1 (rangap1-a) antibody
  • RAN GTPase-activating protein 1 (RANGAP1) antibody
  • ATRANGAP1 antibody
  • C79654 antibody
  • Fug1 antibody
  • mKIAA1835 antibody
  • RANGAP antibody
  • rangap1 antibody
  • rangap1a antibody
  • rangap1b antibody
  • RAN GTPASE-ACTIVATING PROTEIN 1 antibody
  • RAN GTPase activating protein 1 antibody
  • rna1p antibody
  • SD antibody

Protein level used designations for RANGAP1

ran GTPase-activating protein 1 , ran GTPase activating protein 1 , Ran GTPase activating protein 1 , Ran GTPase activating protein 1 b , segregation distorter homolog , segregation distortion , RAN GTPase activating protein 1 , RAN GTPase activating protein 1 a

GENE ID SPECIES
100628308 Equus caballus
100153811 Sus scrofa
10378741 Trichophyton rubrum CBS 118892
100543860 Meleagris gallopavo
616055 Bos taurus
100337588 Xenopus laevis
5905 Homo sapiens
19387 Mus musculus
481234 Canis lupus familiaris
362965 Rattus norvegicus
417997 Gallus gallus
379922 Xenopus laevis
825488 Arabidopsis thaliana
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