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RGS3 encodes a member of the regulator of G-protein signaling (RGS) family. Additionally we are shipping Regulator of G-Protein Signaling 3 Antibodies (39) and Regulator of G-Protein Signaling 3 Proteins (7) and many more products for this protein.
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cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK (show MAP2K1 ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits) signaling
ectopic expression of R4 subfamily members RGS2 (show RGS2 ELISA Kits), RGS3, RGS4 (show RGS4 ELISA Kits), and RGS5 (show RGS5 ELISA Kits) reduced activated PAR1 (show MARK2 ELISA Kits) wild-type signaling, whereas signaling by the PAR1 (show MARK2 ELISA Kits) AKKAA mutant was minimally affected.
PDZ-RGS3 can enhance signals generated by the Wnt (show WNT2 ELISA Kits) canonical pathway and plays a pivotal role in epithelial mesenchymal transition
Results suggest that the 14-3-3 protein (show YWHAE ELISA Kits) binding affects the structure of the Galpha (show SUCLG1 ELISA Kits) interaction portion of RGS3 as well as sterically blocks the interaction between the RGS (show PITX2 ELISA Kits) domain and the Galpha (show SUCLG1 ELISA Kits) subunit of heterotrimeric G proteins.
14-3-3 protein (show YWHAE ELISA Kits) binding induces structural changes in both the N-terminal part and the C-terminal RGS (show PITX2 ELISA Kits) domain of phosphorylated RGS3 molecule
Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure.
Data are consistent with the model wherein 14-3-3 (show YWHAQ ELISA Kits) serves as a scavenger of RGS3, regulating the amounts of RGS3 available for binding G-proteins.
C2PA is expressed in the cell nucleus and induces heat shock response element (HSE (show HSD17B6 ELISA Kits))-dependent gene transcription
RFS3 promoted the conversion of more stable Ca2 (show CA2 ELISA Kits)+ elevations into oscillatory signals.
mRNA expression of CCT5 (show CCT5 ELISA Kits), RGS3, and YKT6 (show YKT6 ELISA Kits) was significantly up-regulated in p53 (show TP53 ELISA Kits)-mutated tumors and associated with a low response rate to docetaxel.
Results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling.
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.
regulator of G-protein signalling 3
, regulator of G-protein signaling 3
, regulator of G-protein signaling 3-like
, regulator of G protein signaling 3
, C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains