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ROM1 is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. Additionally we are shipping ROM1 Antibodies (29) and ROM1 Kits (4) and many more products for this protein.
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Families showing a variable macular dystrophy phenotype caused by mutations in PRPH2 (show PRPH2 Proteins) should be tested for additional mutations in ABCA4 (show ABCA4 Proteins) and ROM1, as they may alter the progression of the PRPH2 (show PRPH2 Proteins) phenotype.
ROM1 overexpression leads to negative effects on cone outer segments ultrastructure and function.
The results suggested that Trp182Arg mutant Rom1 causes a decrease in the levels of wild-type Prph2 (show PRPH2 Proteins) and Rom1.
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.
retinal outer segment membrane protein 1
, rod outer segment membrane protein 1
, retinal outer membrane protein 1
, RDS/peripherin-like protein xRDS35