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Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) ELISA Kits

RPE65 encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. Additionally we are shipping RPE65 Antibodies (56) and RPE65 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RPE65 19892  
RPE65 89826  
RPE65 6121 Q16518
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Top RPE65 ELISA Kits at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 78-5000 pg/mL 96 Tests Log in to see 11 to 13 Days
$946.00
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Mouse
96 Tests Log in to see 11 to 13 Days
$946.00
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Rat
96 Tests Log in to see 11 to 13 Days
$946.00
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Cow
96 Tests Log in to see 11 to 13 Days
$1,029.60
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Chicken
96 Tests Log in to see 11 to 13 Days
$1,095.60
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Dog
96 Tests Log in to see 11 to 13 Days
$1,095.60
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More ELISA Kits for RPE65 Interaction Partners

Zebrafish Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) interaction partners

Mouse (Murine) Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) interaction partners

  1. Influx of T lymphocytes was associated with retinal pigment epithelium and choroidal thinning and diminished expression of RPE65 mRNA, an essential enzyme of the visual cycle.

  2. the RPE65 protein expression was abnormal

  3. These data also help define minimal requirements of chromophore for photoreceptor survival in vivo and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

  4. properties of disease causing RPE65 with regard to molecular pathogenic mechanism

  5. The rd12 lesion is in Rpe65. The rd12 mutant phenotype inherits in a semidominant manner. The effects of the mutant mRNA on visual function may result from inefficient binding to ribosomes for translation.

  6. Despite the previously reported upregulation of Cspg5 (show CSPG5 ELISA Kits) during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 (show CSPG5 ELISA Kits) in disease progression was identified.

  7. To recapitulate this event in vivo, we examined tumor formation in NOG mice after subcutaneous injection of iPSCs with or without an iPSC-derived RPE sheet (2.5 x 10(5) RPE cells).

  8. Cone-opsin (show RHO ELISA Kits) trafficking defects were replicated in Rpe65-/- Rho-/- retina-retinal pigment epithelium cultures.

  9. The Rpe65KO and tvrm148 mutations do not complement one another, proving that the tvrm148 mutation occurs in the Rpe65 locus and is the causative lesion driving visual function loss.

  10. Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.

Cow (Bovine) Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) interaction partners

  1. Data indicate that Structural differences between delipidated and nondelipidated RPE65 uncovered key residues involved in substrate uptake and processing.

  2. oxidative stress during the visual cycle results in cleavage of RPE65

  3. the enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment

  4. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.

  5. retinoid binding role for RPE65

  6. Quenching of protein fluorescence is used to demonstrate quantitatively that RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle.

  7. Rpe65 converts an all-trans-retinyl ester to 11-cis (show CISH ELISA Kits)-retinol and has been identified as retinoid isomerase. Mutations in RPE65 are associated with Leber hereditary optic atrophy

  8. Data show that RPE65 is a moderately specific retinoid binding protein directed at long chain all-trans-retinyl esters.

  9. investigation of metal ions required for the isomerohydrolase activity of RPE65 using the conversion of all-trans-[3H]retinol to 11-cis (show CISH ELISA Kits)-[3H]retinol as the measure for isomerohydrolase activity

  10. LRAT (show LRAT ELISA Kits) is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 with membranes is neither dependent upon LRAT (show LRAT ELISA Kits) nor the result of S-palmitoylation

Human Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) interaction partners

  1. Influx of T lymphocytes was associated with retinal pigment epithelium and choroidal thinning and diminished expression of RPE65 mRNA, an essential enzyme of the visual cycle.

  2. These data also help define minimal requirements of chromophore for photoreceptor survival in vivo and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

  3. three Leber congenital amaurosis -associated RPE65 mutants (R91W, Y249C and R515W) undergo rapid proteasomal degradation mediated by the 26 S proteasome non-ATPase (show DNAH8 ELISA Kits) regulatory subunit 13.

  4. Studies indicate that patients with retinol isomerase RPE65R91W mutation have useful cone-mediated vision in the first decade of life, suggesting partial activity of the mutant RPE65R91W protein.

  5. Data show that 4-phenylbutyrate (PBA) displayed a significant synergistic effect on the low temperature-mediated rescue of the mutant isomerase activity of RPE65.

  6. Expressions of MDSC, FOXP3 (show FOXP3 ELISA Kits)+TILs, and CTLA-4 (show CTLA4 ELISA Kits) are relative stable after nCRT

  7. We showed that miR (show MLXIP ELISA Kits)-410 directly regulates predicted target genes OTX2 (show OTX2 ELISA Kits) and RPE65.

  8. Studies indicate that patients consistently reported improvement in their vision following delivery of recombinant adenoassociated virus (rAAV) that carried retinal pigment epithelium 65 protein (REP65) gene.

  9. All RPE65-mutant observers have consistent and substantial losses in temporal acuity and sensitivity compared with normal observers.

  10. when an amino-terminal fragment (Met(1 (show GZMM ELISA Kits))-Arg(33)) of the N170K/K297G double mutant of hRPE65 was replaced with the corresponding cRPE65 fragment, the isomerohydrolase activity was further increased to a level similar to that of cRPE65.

RPE65 Antigen Profile

Antigen Summary

This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.

Gene names and symbols associated with RPE65

  • retinal pigment epithelium-specific protein 65c (rpe65c) antibody
  • retinal pigment epithelium-specific protein 65kDa (LOC100219959) antibody
  • retinal pigment epithelium-specific protein 65kDa (LOC100352270) antibody
  • retinal pigment epithelium 65 (Rpe65) antibody
  • retinal pigment epithelium-specific protein 65kDa (RPE65) antibody
  • 65kDa antibody
  • A930029L06Rik antibody
  • LCA2 antibody
  • Mord1 antibody
  • mRPE65 antibody
  • rd12 antibody
  • RP20 antibody
  • RPE56c antibody
  • si:ch211-198n5.12 antibody
  • sRPE65 antibody

Protein level used designations for RPE65

All-trans-retinyl ester 13-cis isomerohydrolase C , All-trans-retinylester 11-cis isomerohydrolase C , Retinal pigment epithelium-specific 65 kDa protein homolog C , retinal Mueller cells isomerohydrolase , retinal pigment epithelium-specific protein 65kDa , all-trans-retinyl-palmitate hydrolase , modifier of retinal degeneration 1 , retinal pigment epithelium, 65 kDa , retinal pigment epithelium-specific 65 kDa protein , retinoid isomerohydrolase , retinol isomerase , retinal pigment epithelium 65-like , retinal pigment epithelium-specific protein (65kD) , RBP-binding membrane protein , p63 , retinitis pigmentosa 20 (autosomal recessive) , retinal pigment epithelium abundant protein RPE65 , rpe65 gene for retinal pigment epithelium-specific protein

GENE ID SPECIES
100004076 Danio rerio
100219959 Taeniopygia guttata
100352270 Oryctolagus cuniculus
19892 Mus musculus
89826 Rattus norvegicus
282043 Bos taurus
6121 Homo sapiens
100516743 Sus scrofa
403803 Canis lupus familiaris
395700 Gallus gallus
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