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Direct regulator of SIRT1. Additionally we are shipping RPS19BP1 Antibodies (34) and RPS19BP1 Kits (3) and many more products for this protein.
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AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
In vitro SIRT1 (show SIRT1 Proteins) activity assays disclose AROS as an inhibitor of SIRT1 (show SIRT1 Proteins).
study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1 (show SIRT1 Proteins), promotes survival in cancer cells while being redundant for viability in non-cancer cells
This study analyses Sirt1 (show SIRT1 Proteins) modulation by several putative Sirt1 (show SIRT1 Proteins) regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 (show SIRT1 Proteins) catalytic domain is sufficient for modulation by resveratrol.
we found that the SIRT1 (show SIRT1 Proteins) modulators AROS and DBC1 (show DBC1 Proteins) have an impact on hsp70 (show HSP70 Proteins) transcription, HSF1 (show HSF1 Proteins) acetylation status, and HSF1 (show HSF1 Proteins) recruitment to the hsp70 (show HSP70 Proteins) promoter.
Active regulator of SIRT1 (AROS) is the first direct SIRT1 (show SIRT1 Proteins) regulator to be identified that modulates p53 (show TP53 Proteins)-mediated growth regulation.
identified a novel protein, which was named S19 binding protein (S19BP). No known functional motifs were found in S19BP except a short polylysine tract embedded in a putative nucleolar localization signal.
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).
40S ribosomal protein S19-binding protein 1
, RPS19-binding protein 1
, active regulator of SIRT1
, homolog of mouse S19 binding protein
, S19 binding protein