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The protein encoded by RNF103 contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. Additionally we are shipping Ring Finger Protein 103 Antibodies (39) and many more products for this protein.
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Analysis reveals that the main determinants of selectivity between ubiquitin ligases RNF103 and E2 ubiquitin-conjugating enzymes resides on ring domains, rather than on the E2s.
Kf-1 is an ER ubiquitin ligase involved in the endoplasmic reticulum-associated degradation pathway.
Studies indicate that the kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation.
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.
E3 ubiquitin-protein ligase RNF103
, zinc finger protein 103 homolog
, zinc finger protein expressed in cerebellum
, zinc finger protein 103