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The protein encoded by RNF111 is a nuclear RING-domain containing E3 ubiquitin ligase. Additionally we are shipping RNF111 Antibodies (35) and many more products for this protein.
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Arkadia, but not the C937A (CA) mutant lacking E3 ubiquitin-ligase (show MUL1 Proteins) activity, induced ubiquitylation and proteasome-dependent degradation of Smad6 (show SMAD6 Proteins).
Arkadia enhances transforming growth factor-beta signaling responses and supports its tumor-suppressing properties in colorectal cancer.
RB1CC1 thus appears to play a unique role as a modulator of TGF-beta (show TGFB1 Proteins) signaling by restricting substrate specificity of Arkadia.
Trps1 haploinsufficiency enhances TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.
findings show that Arkadia regulates the levels of expression of c-Ski (show SKI Proteins) protein (show SKIL Proteins) in cell-type-dependent fashion, and exhibits a tumour suppressor function by inhibiting tumour cell growth
Axin (show AXIN1 Proteins) and Arkadia cooperate with each other in promoting Smad7 (show SMAD7 Proteins) ubiquitination.
Arkadia, a nuclear RING-domain E3 ubiquitin ligase (show MUL1 Proteins), is essential for a subset of Nodal functions in the embryo
Arkadia induces degradation of SnoN (show SKIL Proteins) and c-Ski (show SKI Proteins) in addition to Smad7 (show SMAD7 Proteins).
These results suggest that Arkadia targets Ski (show SKI Proteins)-bound, inactive phospho-Smad2 (show SMAD2 Proteins)/3 to regulate positively Myostatin (show MSTN Proteins)/TGF-beta (show TGFB1 Proteins) signaling.
This work presents an efficient method for expression in E. coli and purification of recombinant Arkadia RING finger (show PCGF1 Proteins) domain as a soluble protein.
Results suggest that -459CpG methylation in Sp1 (show PSG1 Proteins)-binding site of RNF111 promoter transcriptionally decreases RNF111 expression, which inhibits TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling associated invasion in NSCLC cells.
Study reports that the monomeric RING domains from the human E3 ligases Arkadia and Ark2C bind directly to free ubiquitin with an affinity comparable to that of other dedicated ubiquitin-binding domains.
These data suggest that RNF111, together with the CRL4(DDB2 (show DDB2 Proteins)) ubiquitin ligase complex, is responsible for sequential XPC (show XPC Proteins) ubiquitylation, which regulates the recruitment and release of XPC (show XPC Proteins) and is crucial for efficient progression of the NER (show NR1H2 Proteins) reaction.
Arkadia can both promote and inhibit gene expression, indicating that Arkadia's activity in transcriptional control may depend on the epigenetic context, defined by Polycomb (show CBX2 Proteins) repressive complexes and DNA methylation (show HELLS Proteins).
Our findings establish RNF111 as a new STUbL that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response.
findings indicate that Arkadia is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis
Arkadia is involved in arsenic-induced degradation of polysumoylated PML (show PML Proteins) protein.
RNF111-dependent neddylation activates DNA damage-induced ubiquitination
FHL2 (show FHL2 Proteins) increases the stability of the TGF-beta (show TGFB1 Proteins) pathway positive regulator Arkadia by inhibiting its ubiquitination and cooperates with Arkadia to activate TGF-beta (show TGFB1 Proteins) signaling.
We established that ARX (show UBA2 Proteins) polyA alterations damage the regulation of KDM5C (show KDM5C Proteins) expression.
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
E3 ubiquitin-protein ligase Arkadia
, hypothetical LOC702104
, ring finger protein 111
, e3 ubiquitin-protein ligase Arkadia-like
, RING finger protein 111
, ring finger 111