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Acts as an E2-dependent E3 ubiquitin-protein ligase. Additionally we are shipping RNF115 Antibodies (34) and many more products for this protein.
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BCA2 functions as an antiviral factor that targets HIV-1 Gag for degradation, impairing virus assembly and release.
BCA2 is an endogenous inhibitor of AMPK (show PRKAA1 Proteins) activation in breast cancer cells and BCA2 inhibition increases the efficacy of metformin.
BCA2, a potential oncogenic E3 ubiquitin ligase (show MUL1 Proteins), promotes breast cancer cell proliferation partially through targeting p21 (show CDKN1A Proteins) for ubiquitination and proteasomal degradation.
RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors.
High BCA2 expression is associated with renal oncocytoma.
BCA2 is therefore a newly identified transcriptional target of estrogen receptor (show ESR1 Proteins).
Rabring7 stimulates c-Myc (show MYC Proteins) degradation via mono-ubiquitination of MM-1 (show PFDN5 Proteins)
BCA2 accelerates the internalization and degradation of viral particles following their tethering to the cell surface and is a co-factor or enhancer for the tetherin (show BST2 Proteins)-dependent restriction of HIV-1 release from infected cells.
BCA2 E3 ligase is coregulated with estrogen receptor (show ESR1 Proteins) and plays a role in the regulation of epidermal growth factor receptor (EGF-R (show EGFR Proteins)) trafficking
These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR (show EGFR Proteins) through its E3 ligase activity.
Rabring7 plays crucial roles as a Rab7 (show RAB7A Proteins) target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis (rabring7)
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.
E3 ubiquitin-protein ligase RNF115
, rabring 7
, zinc finger protein 364
, Rab7-interacting RING finger protein
, RING finger protein 115
, Rabring 7