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E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Additionally we are shipping Ring Finger Protein 144B Antibodies (101) and many more products for this protein.
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findings substantiate PIR2/Rnf144b as a potentially critical component of epithelial homeostasis, acting downstream of DeltaNp63alpha to regulate cellular levels of p21(WAF1/CIP1 (show CDKN1A Proteins)) and DeltaNp63alpha
PIR2/RNF144B/IBRDC2 regulates the stability of TAp73 and DNp73.
IBRDC2, an IBR-type RING-finger (show PCGF1 Proteins) E3 ubiquitin ligase (show MUL1 Proteins), regulates the levels of Bax (show BAX Proteins) and protects cells from unprompted Bax (show BAX Proteins). activation and cell death.
p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.
PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2]
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death\; But, it is not an anti-apoptotic protein per se (By similarity).
E3 ubiquitin-protein ligase RNF144B
, IBR domain containing 2
, IBR domain-containing protein 2
, p53-inducible RING finger protein
, ring finger 144B