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Ring Finger Protein 19A Proteins (RNF19A)

The protein encoded by RNF19A contains two RING-finger motifs and an IBR (in between RING fingers) motif. Additionally we are shipping Ring Finger Protein 19A Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF19A 30945 P50636
RNF19A 25897 Q9NV58
Rat RNF19A RNF19A 362900  
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Top Ring Finger Protein 19A Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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RNF19A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Ring Finger Protein 19A (RNF19A) Interaction Partners

Pig (Porcine) Ring Finger Protein 19A (RNF19A) interaction partners

  1. porcine RNF19 gene maps to chromosome 4 (4p11-p12 (show SPRN Proteins)), consistent with the currently known conservation of genome organization between human and pig.

Mouse (Murine) Ring Finger Protein 19A (RNF19A) interaction partners

  1. These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory.

  2. In addition to causing a decrease in the amount of mutant SOD1 protein in the spinal cord, Dorfin overexpression ameliorated neurological phenotypes and motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.

  3. Dorfin ubiquitylated mutant SOD1 (show SOD1 Proteins) by recognizing the Cys (show DNAJC5 Proteins)(6)- and Cys (show DNAJC5 Proteins)(111)-disulfide cross-linked form and targeted it for proteasomal degradation

Human Ring Finger Protein 19A (RNF19A) interaction partners

  1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease.

  2. Dorfin has a role in ubiquitylating mutant SOD1 (show SOD1 Proteins) proteins and targeting them for proteasomal degradation

  3. results suggest that synphilin-1 (show SNCAIP Proteins) has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 (show SNCAIP Proteins)

  4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis.

  5. Reducing the accumulation of mutant superoxide dismutase 1 (show SOD1 Proteins) [SOD1 (show SOD1 Proteins)] in the mitochondria may be a new therapeutic strategy for mutant SOD1 (show SOD1 Proteins)-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this

  6. Valosin-containing protein (show vcp Proteins) functionally regulates Dorfin through direct interaction

  7. Dorfin-CHIP(L) rescued neuronal cells from mutant SOD1 (show SOD1 Proteins)-associated toxicity and reduced the aggresome formation induced by mutant SOD1 (show SOD1 Proteins) more effectively than did Dorfin(WT).

  8. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition.

Ring Finger Protein 19A (RNF19A) Protein Profile

Protein Summary

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein binds and ubiquitylates synphilin 1 (SNCAIP) which is an interacting protein of alpha synuclein in neurons and a major component of Lewy bodies. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with RNF19A

  • ring finger protein 19 (RFN19)
  • ring finger protein 19A (RNF19A)
  • ring finger protein 19A (Rnf19a)
  • ring finger protein 19A, E3 ubiquitin protein ligase (RNF19A)
  • ring finger protein 19A, E3 ubiquitin protein ligase (Rnf19a)
  • AA032313 protein
  • Dorfin protein
  • Rnf19 protein
  • RNF19A protein
  • Ubce7ip2 protein
  • UIP117 protein
  • XYbp protein

Protein level used designations for RNF19A

E3 ubiquitin-protein ligase RNF19A , RING finger protein 19A , dorfin , double ring-finger protein , UBCM4-interacting protein 117 , XY body protein , gametogenesis-expressed protein GEG-154 , ring finger protein (C3HC4 type) 19 , ubiquitin conjugating enzyme 7 interacting protein 2 , protein p38 interacting with transcription factor Sp1 , ring-IBR-ring domain containing protein Dorfin , ring finger protein 19

GENE ID SPECIES
654326 Sus scrofa
540195 Bos taurus
30945 Mus musculus
25897 Homo sapiens
475049 Canis lupus familiaris
362900 Rattus norvegicus
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