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anti-Ring Finger Protein 8 (RNF8) Antibodies

The protein encoded by RNF8 contains a RING finger motif and an FHA domain. Additionally we are shipping Ring Finger Protein 8 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RNF8 58230 Q8VC56
RNF8 9025 O76064
RNF8 361815 Q4KLN8
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Top anti-Ring Finger Protein 8 Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB RNF8 Antibody (C-term) (ABIN657354) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the RNF8 antibody detected the RNF8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, WB RNF8 Antibody flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of RNF8 Antibody in Jurkat cell line lysates (35µg/lane). RNF8 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN184931 staining (0.1µg/ml) of Human Lung lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of RNF8 in human lung tissue lysate with RNF8 antibody at (A) and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of RNF8 expression in transfected 293T cell line by RNF8 MaxPab polyclonal antibody.Lane 1: RNF8 transfected lysate(53.35 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to RNF8 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated WB RNF8 antibody  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the RNF8 antibody detected the RNF8 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details

RNF8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Ring Finger Protein 8 Antibodies

  1. Human Polyclonal RNF8 Primary Antibody for EIA, WB - ABIN954577 : Noon, Shibata, Rief, Löbrich, Stewart, Jeggo, Goodarzi: 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. in Nature cell biology 2010 (PubMed)
    Show all 5 references for ABIN954577

  2. Human Polyclonal RNF8 Primary Antibody for IF, WB - ABIN522468 : Morris, Boutell, Keppler, Densham, Weekes, Alamshah, Butler, Galanty, Pangon, Kiuchi, Ng, Solomon: The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. in Nature 2009 (PubMed)
    Show all 3 references for ABIN522468

  3. Human Polyclonal RNF8 Primary Antibody for WB - ABIN657354 : Lilley, Chaurushiya, Boutell, Landry, Suh, Panier, Everett, Stewart, Durocher, Weitzman: A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. in The EMBO journal 2010 (PubMed)
    Show all 3 references for ABIN657354

  4. Human Polyclonal RNF8 Primary Antibody for EIA, WB - ABIN783604 : Ito, Adachi, Iwakami, Yasuda, Muto, Seki, Okano: N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. in European journal of biochemistry / FEBS 2001 (PubMed)

  5. Human Polyclonal RNF8 Primary Antibody for ELISA, WB - ABIN184931 : Seki, Hattori, Sugano, Suzuki, Nakagawara, Ohhira, Muramatsu, Hori, Saito: Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif. in Journal of human genetics 1999 (PubMed)

  6. Cow (Bovine) Polyclonal RNF8 Primary Antibody for IHC, WB - ABIN2778597 : Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004 (PubMed)

More Antibodies against Ring Finger Protein 8 Interaction Partners

Mouse (Murine) Ring Finger Protein 8 (RNF8) interaction partners

  1. RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage

  2. Altogether, the data in this study highlight the importance of p53 (show TP53 Antibodies)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (show TP53 Antibodies) functionally interact to protect against genomic instability and tumorigenesis.

  3. The identification of RNF8 allows new insights into the integration of the control of p12 (show CDK2AP1 Antibodies) degradation by different DNA damage signaling pathways.

  4. RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes

  5. A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (show CHD4 Antibodies) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.

  6. Rnf8 physically interacts with Tpp1 (show TPP1 Antibodies) to generate Ubc13 (show UBE2N Antibodies)-dependent Lys63 polyubiquitin (show UBB Antibodies) chains that stabilize Tpp1 (show TPP1 Antibodies) at telomeres.

  7. RNF8 and Chfr (show CHFR Antibodies), function together to activate ATM (show ATM Antibodies) and maintain genomic stability in vivo.

  8. 53BP1 (show TP53BP1 Antibodies) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.

  9. RNF8 deficint mice exhibit increased genomic instability and elevated risks for tumorigenesis indicating that Rnf8 is a novel tumor suppressor.

  10. investigate the role of the ubiquitin ligase (show RNF123 Antibodies) RNF8 during spermatogenesis and find that RNF8-deficient mice are proficient in meiotic sex chromosome inactivation but deficient in global nucleosome removal

Human Ring Finger Protein 8 (RNF8) interaction partners

  1. The interaction of MDC1 (show MDC1 Antibodies) with RNF8, but not with ATM (show ATM Antibodies) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 (show MDC1 Antibodies) by ATM (show ATM Antibodies).

  2. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 (show RNF168 Antibodies) and USP11 (show USP11 Antibodies) to maintain the proper status of ubiquitylation gammaH2AX (show H2AFX Antibodies) to repair double strand breaks.

  3. define a novel function for ATDC (show TRIM29 Antibodies) in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC (show TRIM29 Antibodies)

  4. Results indicate that RNF8 recruits and ubiquitinates many factors to repair DNA damage thereby conferring radioresistance to nasopharyngeal cancer cells.

  5. Significantly restored tolerance of RAD18 (show RAD18 Antibodies)-/- and RNF8-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Antibodies) focus formation.

  6. considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT (show BRDT Antibodies) genes in Chinese patients with non-obstructive azoospermia

  7. our results indicate that down-regulation of RNF8 mediated by miR (show MLXIP Antibodies)-214 impedes DNA damage response to induce chromosomal instability in ovarian cancers, which may facilitate the understanding of mechanisms underlying chromosomal instability.

  8. Finding that RNF8 is less abundant than RNF168 (show RNF168 Antibodies) identifies RNF8 as a rate-limiting determinant of focal repair complex assembly.

  9. Depletion of RNF8 or RNF168 (show RNF168 Antibodies) blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 Antibodies).

  10. PALB2 localization depends on the presence of MDC1, RNF8, RAP80 and Abraxas upstream of BRCA1.

Ring Finger Protein 8 (RNF8) Antigen Profile

Protein Summary

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RNF8

  • ring finger protein 8 (RNF8) antibody
  • ring finger protein 8 (Rnf8) antibody
  • ring finger protein 8, E3 ubiquitin protein ligase (RNF8) antibody
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8-a) antibody
  • ring finger protein 8, E3 ubiquitin protein ligase (Rnf8) antibody
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8) antibody
  • 3830404E21Rik antibody
  • AIP37 antibody
  • fc66f09 antibody
  • hRNF8 antibody
  • RNF8 antibody
  • wu:fc66f09 antibody
  • zgc:55936 antibody
  • zgc:77313 antibody

Protein level used designations for RNF8

E3 ubiquitin-protein ligase RNF8 , ActA binding protein 2 , actA-interacting protein 37 , laXp180 , C3HC4-type zinc finger protein , UBC13/UEV-interacting ring finger protein , ring finger protein (C3HC4 type) 8 , E3 ubiquitin-protein ligase RNF8 A , E3 ubiquitin-protein ligase RNF8-A , RING finger protein 8 A , RING finger protein 8-A

GENE ID SPECIES
515933 Bos taurus
58230 Mus musculus
9025 Homo sapiens
380076 Xenopus laevis
361815 Rattus norvegicus
481775 Canis lupus familiaris
100173982 Pongo abelii
404050 Danio rerio
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