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RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). Additionally we are shipping RC3H1 Antibodies (31) and RC3H1 Proteins (3) and many more products for this protein.
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RC3H1 is a multifunctional regulator of immune homeostasis. (Review)
The authors unexpectedly uncover a ROQUIN-AMPK (show PRKAA1 ELISA Kits) metabolic signaling nexus essential for selectively promoting T follicular helper cell responses.
Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 (show TNFRSF4 ELISA Kits) 3'-UTR (show UTS2R ELISA Kits) with identical binding modes.
Roquin also directly binds Argonaute2 (show EIF2C2 ELISA Kits), a central component of the RNA-induced silencing complex, and miR (show MLXIP ELISA Kits)-146a, a microRNA that targets Icos (show ICOS ELISA Kits) mRNA.
small intestinal inflammation in Rc3h1(san/san) and Rc3h1(gt/gt (show FABP6 ELISA Kits)) mice is due to a failure of Roquin expression in the immune system and not to insufficient systemic Roquin expression.
Over-expression of Roquin exacerbates T-cell mediated hepatitis.
Roquin inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6 (show IL6 ELISA Kits), ICOS (show ICOS ELISA Kits), c-Rel (show NFkBP65 ELISA Kits), IRF4 (show IRF4 ELISA Kits), IkappaBNS and IkappaBzeta (show NFKBIZ ELISA Kits).
Results show an opposing relationship between Roquin-1 and the IL-17a (show IL17A ELISA Kits) proinflammatory cytokine. Enforced expression of Rc3h1 restricts Il17a (show IL17A ELISA Kits) expression, and exposure of T cells to IL-10 (show IL10 ELISA Kits) increases Rc3h1 expression.
Roquin makes mainly non-sequence-specific contacts to the RNA, binding a more relaxed constitutive decay element consensus sequence than previously thought.
Study shows that neither alteration of ROQUIN gene nor deregulation of miR101 expression is likely to be a frequent recurrent event in AITL.
Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions.
A distinct, sequence-induced conformation is required for recognition of the constitutive decay element RNA by Roquin.
Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation.
RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs. Knockdown of RC3H1 resulted in increased A20 (show TNFAIP3 ELISA Kits) protein expression, thereby interfering with IkappaB kinase (show CHUK ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) activities.
In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline (show ZFP36 ELISA Kits), Roquins, and Regnase-1.
Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin depends on their translation status and enables elaborate control of inflammation.
Roquin-mediated degradation of HMGXB3 and IL6 (show IL6 ELISA Kits) mRNAs in human cells, demonstrates the importance of both binding sites for mRNA decay.
Excessive interferon (IFN)-gamma (show IFNA ELISA Kits) signaling promotes accumulation of Roquin-mutated, short-lived effector-like CD8 (show CD8A ELISA Kits)+ T cells in autoimmune-prone transgenic mice.
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005
RING CCCH (C3H) domains 1
, ring finger and CCCH-type zinc finger domains 1
, ring finger and CCCH-type domains 1
, RING finger and C3H zinc finger protein 1
, probable E3 ubiquitin-protein ligase Roquin
, protein Sanroque
, RING finger protein 198