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Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) Proteins (ROBO2)

ROBO2 belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. Additionally we are shipping ROBO2 Antibodies (67) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ROBO2 268902  
ROBO2 6092 Q9HCK4
Rat ROBO2 ROBO2 84409  
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Top ROBO2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ROBO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , , , ,
, ,

More Proteins for Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) Interaction Partners

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. Genetic analysis showed that Caspase-3 (show CASP3 Proteins), Caspase-9 (show CASP9 Proteins), and p38 MAPK (show MAPK14 Proteins) interacted with Slit1a-Robo2 signaling.

  2. The N-terminal domain unique to Robo3a (show ROBO3 Proteins).1 mediates blockade of Robo2 repulsive activity.

  3. Robo2-Slit and Dcc (show DCC Proteins)-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.

  4. These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.

  5. Increased arborization in robo2 mutants was phenocopied by dominant-negative Robo2 expressed in single retinal ganglion cells and rescued by full-length Robo2, indicating that Robo2 acts cell-autonomously.

  6. Robo2 acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. Robo1 (show ROBO1 Proteins)/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice

  2. Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.

  3. Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium.

  4. Mutations of the SLIT2 (show SLIT2 Proteins)-ROBO2 pathway genes SLIT2 (show SLIT2 Proteins) and SRGAP1 (show SRGAP1 Proteins) confer risk for congenital anomalies of the kidney and urinary tract

  5. Slit2 (show SLIT2 Proteins) signaling through Robo1 (show ROBO1 Proteins) and Robo2 has a role in retinal neovascularization

  6. Mycbp2 and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance

  7. Report role of Robo2 in development of the caval veins and pericardium.

  8. Inactivation of Robo 2 leads to mispositioning of the stomach in the thoracic instead of the abdominal cavity, which likely contributes to poor lung inflation and lethality at birth, reminiscent of congenital diaphragmatic hernia.

  9. Robo2 signaling acts as a negative regulator on nephrin (show NPHS1 Proteins) to influence podocyte foot process architecture.

  10. Gbx2 (show GBX2 Proteins) regulates thalamocortical axon guidance by modifying the LIM (show PDLIM5 Proteins) and Robo codes.

Human Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer

  2. ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired.

  3. Common variation near ROBO2 is associated with expressive vocabulary in infancy.

  4. Mutations of the SLIT2 (show SLIT3 Proteins)-ROBO2 pathway genes SLIT2 (show SLIT3 Proteins) and SRGAP1 (show SRGAP1 Proteins) confer risk for congenital anomalies of the kidney and urinary tract

  5. Down-regulation of ROBO2 expression is associated with prostate cancers.

  6. Frameshift mutations of ROBO1 (show ROBO1 Proteins) and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers.

  7. The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy.

  8. Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be.

  9. data suggests the importance of abrogation of SLIT2 (show SLIT3 Proteins)-ROBO1 (show ROBO1 Proteins) and SLIT2 (show SLIT3 Proteins)-ROBO2 interactions in the initiation and progression of CACX and also for early diagnosis and prognosis of the disease

  10. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

ROBO2 Protein Profile

Protein Summary

This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with ROBO2

  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2)
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (LOC100221297)
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (robo2)
  • roundabout homolog 2 (robo2)
  • roundabout homolog 2 (Drosophila) (Robo2)
  • roundabout homolog 2-like (LOC534842)
  • roundabout, axon guidance receptor, homolog 2 (robo2)
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (Robo2)
  • 2600013A04Rik protein
  • 9430089E08Rik protein
  • BB097918 protein
  • D230004I22Rik protein
  • mKIAA1568 protein
  • ROBO2 protein
  • SAX3 protein
  • unp1881 protein

Protein level used designations for ROBO2

roundabout, axon guidance receptor, homolog 2 (Drosophila) , roundabout homolog 2-like , ast , astray , zmp:0000000549 , roundabout homolog 2 , roundabout, axon guidance receptor, homolog 2 , Robo 2 , roundabout-2 , roundabout 2 precursor , Roundabout2 protein

GENE ID SPECIES
100068957 Equus caballus
460517 Pan troglodytes
100221297 Taeniopygia guttata
100388667 Callithrix jacchus
100493913 Xenopus (Silurana) tropicalis
100545405 Meleagris gallopavo
100567276 Anolis carolinensis
60309 Danio rerio
268902 Mus musculus
534842 Bos taurus
100462919 Xenopus laevis
6092 Homo sapiens
487691 Canis lupus familiaris
84409 Rattus norvegicus
395291 Gallus gallus
100739586 Sus scrofa
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