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SEC23IP encodes a member of the phosphatidic acid preferring-phospholipase A1 family. Additionally we are shipping SEC23 Interacting Protein Antibodies (46) and SEC23 Interacting Protein Proteins (4) and many more products for this protein.
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The Drosophila proteinin CG8552 is a phosphatidic acid phospholipase A1 and mediates endoplasmic reticulum-Golgi transit of a family of G protein-coupled receptors.
A basic cluster and a hydrophobic interface in the DDHD and SAM (show TTN ELISA Kits) domains, respectively, are required for p125A-mediated functional endoplasmic reticulum exit site assembly.
Xenopus sec23ip is required for normal neural crest cell development, suggesting a role for the human ortholog in Waardenburg syndrome neural crest defects.
The results suggest that p125A is part of the Sec13 (show SEC13 ELISA Kits)/Sec31A (show SEC31A ELISA Kits) subcomplex and facilitates ER export in mammalian cells.
p125 (show XPC ELISA Kits) is a mammalian-specific component of ER exit sites and participates in the organization of this compartment
These results suggest that p125/Sec23-interacting protein plays an important role in spermiogenesis.
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene.
, SEC23 interacting protein
, Sec23-interacting protein p125
, Sec23-interacting protein
, SEC23-interacting protein-like