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SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4.
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Human Polyclonal SETD1A Primary Antibody for WB - ABIN1881793
Lee, Skalnik: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. in The Journal of biological chemistry 2005
Show all 6 references for ABIN1881793
Human Polyclonal SETD1A Primary Antibody for ICC, IF - ABIN4353047
Cho, Shimazu, Toyokawa, Daigo, Maehara, Hayami, Ito, Masuda, Ikawa, Field, Tsuchiya, Ohnuma, Ponder, Yoshida, Nakamura, Hamamoto: Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. in Nature communications 2012
Given the critical tumor suppressor role of p53 (show TP53 Antibodies), SETD1A-mediated suppression of this pathway (even in the absence of p53 (show TP53 Antibodies) mutations), would be predicted to have profound consequences on tumorigenesis.
Findings provide evidence that SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically.
Loss-of-function variants in SETD1A cause a range of neurodevelopmental disorders in a Finnish population.
Set1 role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Antibodies),Myc (show MYC Antibodies),Sox2 (show SOX2 Antibodies) and Ash2l (show ASH2L Antibodies) reprogramming factors
This study demonstrated that SETD1A mutation showing the highest statistical significance in Autism and Schizophrenia.
suppresses BTG2 (show BTG2 Antibodies) expression through its induction of several BTG2 (show BTG2 Antibodies)-targeting miRNAs
Set1/MLL complex is indispensable for the transcriptional ability of HSF2.
Study reveals that SETD1A controls tumor metastasis by activating matrix metalloproteinases (MMP) expression and provides an epigenetic link among SETD1A, MMPs, and metastasis of breast cancer.
results demonstrate a novel function of BAF (show BANF1 Antibodies) as an epigenetic regulator of HSV lytic infection; hypothesize that BAF (show BANF1 Antibodies) facilitates Herpes Simplex Virus IE and E gene expression by recruiting the SETD1A methyltransferase to viral IE and E gene promoters
Based on our structural data and cross-linking results, we suggest that Dpy30 (show DPY30 Antibodies) may regulate H3K4 methylation according to its copy number in COMPASS
our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Antibodies), Sox2 (show SOX2 Antibodies), Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Antibodies) and early development
revealed a critical role of Setd1a and its mediated epigenetic modifications in regulating the IgH rearrangement and B-cell development
The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b (show SETD1B Antibodies) becomes essential after gastrulation.
embryonic stem cells lacking Cfp1 (CXXC1 (show CXXC1 Antibodies)(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 (show CXXC1 Antibodies) functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex.
mNSC1 lacks protein-coding capacity
SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005
SET domain containing 1A
, histone-lysine N-methyltransferase SETD1A
, histone-lysine N-methyltransferase SETD1-like protein
, histone-lysine N-methyltransferase SETD1A-like
, SET domain-containing protein 1A
, lysine N-methyltransferase 2F
, set1/Ash2 histone methyltransferase complex subunit SET1
, non-selective cation channel 1