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SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]..
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we propose histone demethylase (show MBD2 Antibodies) KDM2B (show KDM2B Antibodies) and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies
We analyzed SETD1B expression in gastric and colorectal cancer. Loss of SETD1B was identified in 15% to 55% of the GC and CRC (show CALR Antibodies) with respect to the microsatellite instability status. Loss of expression was more common in those with SETD1B mutations.
both Rbm15 (show RBM15 Antibodies) and the leukemogenic Rbm15 (show RBM15 Antibodies)-Mkl1 (show MKL1 Antibodies) fusion protein interact with the Setd1b histone H3 (show HIST3H3 Antibodies)-Lys4 methyltransferase
Expression profiling of Setd1b(Gdf9 (show GDF9 Antibodies)) cKO MII oocytes revealed (1) that Setd1b promotes the expression of the major oocyte transcription factors including Obox1, 2, 5, 7, Meis2 (show MEIS2 Antibodies) and Sall4 (show SALL4 Antibodies); and (2) twice as many mRNAs were upregulated than downregulated, suggesting that Setd1b also promotes the expression of negative regulators of oocyte development with multiple Zfp (show ZNF167 Antibodies)-KRAB factors implicated.
The H3K4 methyltransferase Setd1a (show SETD1A Antibodies) is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007
SET domain-containing protein 1B
, histone-lysine N-methyltransferase SETD1B
, lysine N-methyltransferase 2G