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Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3.
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Human Polyclonal SETD8P1 Primary Antibody for WB - ABIN387998
Chuikov, Kurash, Wilson, Xiao, Justin, Ivanov, McKinney, Tempst, Prives, Gamblin, Barlev, Reinberg: Regulation of p53 activity through lysine methylation. in Nature 2004
Show all 5 references for ABIN387998
These findings underscore the role of KMT7 as an important monomethyltransferase regulating HIV transcription through Tat (show TAT Antibodies).
High SET7 (show SETD7 Antibodies) expression is associated with breast cancer.
SET7 (show SETD7 Antibodies) was required for GATA1 (show GATA1 Antibodies)-induced breast tumor angiogenesis and growth in nude mice. GATA1 (show GATA1 Antibodies) and SET7 (show SETD7 Antibodies) are independent poor prognostic factors in breast cancer.
SET7/SET9-mediated YY1 (show YY1 Antibodies) methylation was shown to be involved in YY1 (show YY1 Antibodies)-regulated gene transcription and cell proliferation.
These results demonstrate that S...O chalcogen bonds contribute to AdoMet (show MAT1A Antibodies) recognition and can enable methyltransferases to distinguish between substrate and product.
Reduced expression of SET7 (show SETD7 Antibodies) is associated with gastric cancer progression.
study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 (show SETD7 Antibodies) and lycopene, both independently associated with prostate cancer.
Lysine methylation by SETD7 (show SETD7 Antibodies) is important for the fine-tuning of reactive oxygen species signaling through its regulation on pro-inflammatory responses.
Knock-down of SETD7 (show SETD7 Antibodies) causes differentiation defects in human embryonic stem cell including delay in both the silencing of pluripotency-related genes and the induction of differentiation genes.
Unleashed expression of Mdm2 (show MDM2 Antibodies) in cancer patients with diminished expression of Set7/9 is associated with poor survival outcome.
We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells.
SETD7 (show SETD7 Antibodies) is required for Wnt (show WNT2 Antibodies)-driven intestinal tumorigenesis and regeneration. SETD7 (show SETD7 Antibodies)-dependent methylation of YAP (show YAP1 Antibodies) facilitates Wnt (show WNT2 Antibodies)-induced nuclear accumulation of beta-catenin (show CTNNB1 Antibodies).
SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.
Data indicate that the ability of transcription factor Pdx1 (show PDX1 Antibodies) to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.
study found that Set7 (show SETD7 Antibodies) is a modifier of the Hippo pathway. Mice that lack Set7 (show SETD7 Antibodies) have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.
The response to hyperglycemia in vascular endothelial cells involves Set7 (show SETD7 Antibodies) mediated changes in chromatin remodeling and gene expression.
Set7/9-mediated methylation of p53 (show TP53 Antibodies) does not represent a major regulatory event and does not appreciably control p53 (show TP53 Antibodies) activity in vivo.
Set7/9 is dispensable for p53 (show TP53 Antibodies) function in the mouse.
Define a biological function for Set7 (show SETD7 Antibodies) in muscle differentiation and provide a molecular mechanism by which Set7 (show SETD7 Antibodies) modulates myogenic transcription factors during muscle differentiation.
Pdx1 (show PDX1 Antibodies)-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
, SET domain-containing protein 7
, histone H3-K4 methyltransferase SETD7
, histone H3-lysine 4-specific methyltransferase
, histone-lysine N-methyltransferase SETD7
, lysine N-methyltransferase 7
, H3-K4 methyltransferase