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SET Domain and Mariner Transposase Fusion Gene Proteins (SETMAR)

SETMAR encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. Additionally we are shipping SETMAR Antibodies (33) and SETMAR Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SETMAR 6419 Q53H47
SETMAR 74729 Q80UJ9
SETMAR 500281 Q5I0M0
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Top SETMAR Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
HOST_Baculovirus Human DYKDDDDK Tag Recombinant SETMAR protein gel. SETMAR protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SETMAR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for SET Domain and Mariner Transposase Fusion Gene (SETMAR) Interaction Partners

Human SET Domain and Mariner Transposase Fusion Gene (SETMAR) interaction partners

  1. The SET domain is needed for the 5' end of ss-overhang cleavage with fork and non-fork DNA without affecting the Metnase-DNA interaction. This domain has a positive role in restart of replication fork and the 5' end of ss-overhang cleavage.

  2. methylation of snRNP70 (show SNRNP70 Proteins) by SETMAR regulates constitutive and/or alternative splicing

  3. Metnase may possess an important role in DNA repair, topoisomerase II (show TOP2 Proteins) function, and the maintenance of stemness during colon cancer development.

  4. 293 T transfected with Metnase revealed a large number of rescued plasmids.

  5. found known and novel SETMAR splice variants to be significantly increased in acute myeloid leukemia (show BCL11A Proteins)

  6. a single mutation DDN(610) --> DDD (show KRT5 Proteins)(610), which restores the ancestral catalytic site, results in loss of function in Metnase

  7. phosphorylation of Metnase S495 differentiates between these two functions, enhancing DSB repair and repressing replication fork restart.

  8. Data show that DBN1 (show DBN1 Proteins), SETMAR and HIG2 (show HILPDA Proteins) are direct transcriptional targets of the SOX11 (show SOX11 Proteins) protein.

  9. DNA repair protein (show ATRIP Proteins) Metnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and directly mediated the formation of H3K36me2 near the induced DSB

  10. results establish Metnase as a key factor that promotes restart of stalled replication forks, and implicate Metnase in the repair of collapsed forks.

Mouse (Murine) SET Domain and Mariner Transposase Fusion Gene (SETMAR) interaction partners

  1. The suppression of Notch-1 (show NOTCH1 Proteins) led to increased expression of Oct4 (show POU5F1 Proteins) and Sox2 (show SOX2 Proteins), but in decreased gene expression of cMET, Setmar and CD44 (show CD44 Proteins).

  2. Metnase may have been selected for because it has a function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity.

SETMAR Protein Profile

Protein Summary

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SETMAR

  • SET domain and mariner transposase fusion gene (SETMAR)
  • SET domain without mariner transposase fusion (SETMAR)
  • SET domain without mariner transposase fusion (setmar)
  • SET domain and mariner transposase fusion gene (setmar)
  • SET domain without mariner transposase fusion (Setmar)
  • 5830404F24Rik protein
  • Etet2 protein
  • HsMar1 protein
  • Mar1 protein
  • METNASE protein
  • MGC151518 protein
  • SETMAR protein
  • zgc:172212 protein

Protein level used designations for SETMAR

SET domain and mariner transposase fusion gene , histone-lysine N-methyltransferase SETMAR , SET domain and mariner transposase fusion , SET domain without mariner transposase fusion , metnase , histone-lysine N-methyltransferase SETMAR-like , SET domain and mariner transposase fusion gene-containing protein , SET domain and mariner transposase fusion gene-containing protein homolog , epidermal tumor expressed transcript 2

GENE ID SPECIES
427598 Gallus gallus
470738 Pan troglodytes
476549 Canis lupus familiaris
564575 Danio rerio
703880 Macaca mulatta
100135741 Xenopus (Silurana) tropicalis
100447656 Pongo abelii
100586616 Nomascus leucogenys
534913 Bos taurus
6419 Homo sapiens
511299 Bos taurus
74729 Mus musculus
500281 Rattus norvegicus
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