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SH2B Adaptor Protein 1 (SH2B1) ELISA Kits

SH2B1 encodes a member of the SH2-domain containing mediators family. Additionally we are shipping SH2B Adaptor Protein 1 Antibodies (62) and SH2B Adaptor Protein 1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SH2B1 SH2B1 25970 Q9NRF2
Anti-Mouse SH2B1 SH2B1 20399 Q91ZM2
Anti-Rat SH2B1 SH2B1 89817 Q62985
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More ELISA Kits for SH2B Adaptor Protein 1 Interaction Partners

Human SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  2. Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.

  3. The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.

  4. 4 novel variants in SH2B1 were identified in individuals with obesity and insulin (show INS ELISA Kits) resistance.

  5. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2 (show FAIM2 ELISA Kits), in the risk of overweight/obesity.

  6. SH2B1 can enhance neurite outgrowth and accelerate the maturation of human induced neurons under defined conditions.

  7. Data (from in excess of six genetic association studies) suggest that an SNP in SH2B1 (rs4788102) is not associated with abnormal glucose homeostasis in obese subjects of European ancestry. [META-ANALYSIS]

  8. Data show the synthetic effect of SNPs on the indices of adiposity and risk of obesity in Chinese girls, but failed to replicate the effect of five separate variants of SEC16B (show SEC16B ELISA Kits) rs10913469, SH2B1 rs4788102, PCSK1 (show PCSK1 ELISA Kits) rs6235, KCTD15 rs29941 and BAT2 (show BAT2 ELISA Kits) rs2844479.

  9. Common variants near BDNF (show BDNF ELISA Kits) and SH2B1 show nominal evidence of association with snacking behavior in European populations.

  10. rare missense mutations of FTO and SH2B1 did not confer risks of obesity in Chinese Han children in our cohort

Mouse (Murine) SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  2. SH2B1 in pancreatic beta-cells promotes insulin (show INS ELISA Kits) synthesis and secretion at least in part by enhancing activation of JAK2 (show JAK2 ELISA Kits) and/or Pdx1 (show PDX1 ELISA Kits) pathways in response to hormonal and nutritional signals.

  3. hepatic SH2B1 is not required for the maintenance of normal insulin (show INS ELISA Kits) sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.

  4. These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin (show INS ELISA Kits)-resistant state and in response to beta-cell stress.

  5. SH2B1 is responsive to erythropoietin (show EPO ELISA Kits) stimulation and becomes phosphorylated

  6. Leptin (show LEP ELISA Kits)-stimulated activation of hypothalamic JAK2 (show JAK2 ELISA Kits) and phosphorylation of hyphothalamic IRS2 (show IRS2 ELISA Kits) were significantly impaired in SH2B1(-/-) mice.

  7. Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.

  8. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.

  9. These results suggest that SH2-Bbeta regulation of Akt (show AKT1 ELISA Kits) partly participates in the NGF (show NGFB ELISA Kits)-mediated development of allergic airway challenge.

  10. These results suggest that 1) SH2-B beta specifically activates JAK2 (show JAK2 ELISA Kits), 2) APS (show SH2B2 ELISA Kits) negatively regulates both JAK2 (show JAK2 ELISA Kits) and JAK1 (show JAK1 ELISA Kits), and 3) both SH2-B beta and APS (show SH2B2 ELISA Kits) may serve as adapter proteins for all three JAKs independent of any role they have in JAK (show JAK3 ELISA Kits) activity.

SH2B Adaptor Protein 1 (SH2B1) Antigen Profile

Antigen Summary

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with SH2B1

  • SH2B adaptor protein 1 (SH2B1) antibody
  • SH2B adaptor protein 1 (sh2b1) antibody
  • SH2B adaptor protein 1 (Sh2b1) antibody
  • AI425885 antibody
  • C530001K22Rik antibody
  • Irip antibody
  • mKIAA1299 antibody
  • PSM antibody
  • Sh2-b antibody
  • SH2-Bb antibody
  • Sh2b antibody
  • SH2B3 antibody
  • Sh2bpsm1 antibody
  • zgc:158474 antibody

Protein level used designations for SH2B1

SH2B adapter protein 1 , SH2B adaptor protein 1 , SH2B adapter protein 1-like , SH2 domain-containing protein 1B , SH2 domain-containing putative adapter SH2-B , SH2-B signaling protein , pro-rich, PH and SH2 domain-containing signaling mediator , PSM , SH2-B PH domain containing signaling mediator 1 , SH2-B PH domain-containing signaling mediator 1 , fceRI gamma-chain-interacting protein SH2-B

GENE ID SPECIES
506066 Bos taurus
558152 Danio rerio
708160 Macaca mulatta
100064371 Equus caballus
100385268 Callithrix jacchus
100470297 Ailuropoda melanoleuca
100587926 Nomascus leucogenys
25970 Homo sapiens
20399 Mus musculus
89817 Rattus norvegicus
612792 Canis lupus familiaris
100516788 Sus scrofa
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