anti-SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibodies

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Additionally we are shipping SHANK2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SHANK2 22941 Q9UPX8
SHANK2 171093 Q9QX74
SHANK2 210274 Q80Z38
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Top anti-SHANK2 Antibodies at antibodies-online.com

Showing 10 out of 144 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB SHANK2 Antibody (Center) (ABIN656710) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SHANK2 Antibody (Center) in Mouse bladder tissue lysates (35ug/lane).This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from RAW264.7/Jurkat/HepG2/COLO cells, using SHANK2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, IP, WB Shank2 Rat Brain Membrane Western Blotting. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of SHANK2 expression in Jurkat (A), IMR32 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Rat Mouse Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot: SHANK2 Antibody (S23b-49) [NBP2-12913] - analysis of Rat brain membrane lysate showing detection of SHANK protein using Mouse Anti-SHANK Monoclonal Antibody, Clone S23b-49 . Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SHANK Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$451.00
Details

SHANK2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SHANK2 Antibodies

  1. Mammalian Monoclonal SHANK2 Primary Antibody for ISt, IHC - ABIN1304902 : Gill, Droubi, Giovedi, Fedder, Bury, Bosco, Sceniak, Benfenati, Sabo: Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. in Journal of cell science 2015 (PubMed)
    Show all 26 Pubmed References

  2. Mammalian Monoclonal SHANK2 Primary Antibody for ISt, IHC - ABIN1304953 : Peykov, Berkel, Schoen, Weiss, Degenhardt, Strohmaier, Weiss, Proepper, Schratt, Nöthen, Boeckers, Rietschel, Rappold: Identification and functional characterization of rare SHANK2 variants in schizophrenia. in Molecular psychiatry 2015 (PubMed)
    Show all 12 Pubmed References

  3. Human Monoclonal SHANK2 Primary Antibody for AA, ICC - ABIN863120 : Nagura, Ishikawa, Kobayashi, Takao, Tanaka, Nishikawa, Tamura, Shiosaka, Suzuki, Miyakawa, Fujiyoshi, Doi et al.: Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 ... in Molecular brain 2013 (PubMed)

More Antibodies against SHANK2 Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla

  2. variants in the SHANK2 gene in a schizophrenia patient cohort

  3. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (show CFTR Antibodies).

  4. syndapin I (show PACSIN1 Antibodies) functions reflected direct, SH3 domain (show ITSN1 Antibodies)-mediated associations and functional interactions with ProSAP1/Shank2.

  5. Lack of association between NLGN3 (show NLGN3 Antibodies), NLGN4 (show NLGN4X Antibodies), SHANK2 and SHANK3 (show SHANK3 Antibodies) gene variants and autism spectrum disorder in a Chinese population.

  6. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate (show GRIN1 Antibodies) receptors at the synapse and increased levels of ProSAP2/Shank3 (show SHANK3 Antibodies)

  7. we confirmed that de novo SHANK2 deletions are present in patients with ASD (show ARSD Antibodies) and showed that several SHANK2 variants reduce the number of synapses in vitro

  8. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (show ARSD Antibodies)

  9. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD (show ARSD Antibodies)) and mental retardation

  10. betaPix (show ARHGEF7 Antibodies) up-regulates NHE3 (show SLC9A3 Antibodies) membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK (show EPHB2 Antibodies) signaling in spinal pain transmission.

  2. We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors.

  3. Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.

  4. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice

  5. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  6. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  7. syndapin I (show PACSIN1 Antibodies) functions reflected direct, SH3 domain (show ITSN1 Antibodies)-mediated associations and functional interactions with ProSAP1/Shank2.

  8. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

  9. Shank2 negatively regulates CFTR (show CFTR Antibodies) and this may play a significant role in maintaining epithelial homeostasis

  10. Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina.

SHANK2 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Gene names and symbols associated with SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2) antibody
  • SH3/ankyrin domain gene 2 (shank2) antibody
  • SH3 and multiple ankyrin repeat domains 2 (LOC100338286) antibody
  • SH3 and multiple ankyrin repeat domains 2 (Shank2) antibody
  • SH3 and multiple ankyrin repeat domains 2 (shank2) antibody
  • SH3/ankyrin domain gene 2 (Shank2) antibody
  • auts17 antibody
  • cortbp1 antibody
  • cttnbp1 antibody
  • MGC122482 antibody
  • mKIAA1022 antibody
  • prosap1 antibody
  • SHANK antibody
  • SHANK2 antibody
  • spank-3 antibody

Protein level used designations for SHANK2

SH3 and multiple ankyrin repeat domains 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , GKAP/SAPAP-interacting protein , SH3/ankyrin domain gene 2 , proline rich synapse associated protein 1 , cortBP1

GENE ID SPECIES
428858 Gallus gallus
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
466694 Pan troglodytes
708192 Macaca mulatta
747845 Pan troglodytes
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
22941 Homo sapiens
171093 Rattus norvegicus
483677 Canis lupus familiaris
618649 Bos taurus
734458 Xenopus laevis
210274 Mus musculus
Selected quality suppliers for anti-SHANK2 (SHANK2) Antibodies
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