You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) Antibodies

SHANK3 is a member of the Shank gene family. Additionally we are shipping SHANK3 Kits (1) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SHANK3 85358 Q9BYB0
SHANK3 59312 Q9JLU4
SHANK3 58234 Q4ACU6
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SHANK3 Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ICC, IF, IP, IHC, WB Shank3 Brain Membrane Western Blotting. 100 μg Log in to see 3 to 4 Days
$383.90
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunohistochemistry of SHANK3 in human brain tissue with SHANK3 antibody at 2.5 ug/mL. Western blot analysis of SHANK3 in 3T3 cell lysate with SHANK3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IHC (fro), IF, IP, WB 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$420.00
Details
Rat Mouse Un-conjugated ICC, IP, IHC, WB   100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-SHANK3 Polyclonal Antibody, Unconjugated (ABIN1386707) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Rat Rabbit Un-conjugated ICC, IHC, WB dilution: 1 : 1000, sample: rat hippocampus homogenate Indirect immunolabeling of PFA fixed rat hippocampus neurons with anti-shank 3 (dilution 1 : 500; red), counterstained with mouse anti-synapsin 1 (cat. no. 106 001, dilution 1 : 500; green). 200 μL Log in to see 5 to 6 Days
$358.05
Details
Mouse Mouse HRP ICC, IF, IHC, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Human Mouse HRP ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Mouse Mouse FITC ICC, IF, IHC, WB   100 μg Log in to see 3 to 4 Days
$426.80
Details

SHANK3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, ,
,
, , , , , , , , , , , , , , , , , , ,
Rat (Rattus) ,
, ,
,
, , , , , , , , , , , , , , , , , , ,
Mouse (Murine) ,
, ,
,
, , , , , , , , , , , , , , , , , , ,

Top referenced anti-SHANK3 Antibodies

  1. Human Polyclonal SHANK3 Primary Antibody for EIA, IF - ABIN1449931 : Sheng, Kim: The Shank family of scaffold proteins. in Journal of cell science 2000 (PubMed)
    Show all 2 references for ABIN1449931

  2. Human Monoclonal SHANK3 Primary Antibody for ICC, IF - ABIN863129 : Durand, Betancur, Boeckers, Bockmann, Chaste, Fauchereau, Nygren, Rastam, Gillberg, Anckarsäter, Sponheim, Goubran-Botros, Delorme, Chabane, Mouren-Simeoni, de Mas, Bieth, Rogé, Héron, Burglen, Gillberg, Leboyer, Bourgeron: Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. in Nature genetics 2006 (PubMed)

  3. Rat (Rattus) Polyclonal SHANK3 Primary Antibody for ICC, IHC - ABIN1742347 : Tao-Cheng, Toy, Winters, Reese, Dosemeci: Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses. in PLoS ONE 2016 (PubMed)

More Antibodies against SHANK3 Interaction Partners

Zebrafish SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

Human SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7 (show LILRB1 Antibodies), miR (show MLXIP Antibodies)-34a, and miR (show MLXIP Antibodies)-504, is reported.

  2. these data suggest that SHANK3 mutations predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to pharmacological intervention.

  3. De novo SHANK3 mutation causes Rett syndrome-like phenotype in a female patient.

  4. miR-7 (show LILRB1 Antibodies) binds to 3-prime untranslated regions of SHANK3 mRNA and causes the alteration of neuronal morphology and function, potentially playing a crucial role in the pathophysiological process of schizophrenia

  5. a mutation in SHANK3 that underscores its relevance in Autism Spectrum Disorder.

  6. This study identified and confirmed SHANK3 protein changes within the postsynaptic density in schizophrenia

  7. because the deletions in our patients do not involve the SHANK3 gene, we posit the existence of a new contiguous gene syndrome proximal to the smallest terminal deletions in the 22q13 region.

  8. This study is the first to identify specific chromosome 22q13.2q13.32 genomic regions, in addition to the terminal 22q13.33 genomic region encompassing SHANK3, associated with key phenotypes in Phelan-McDermid syndrome.

  9. The ability to alter the epigenetic modification and expression of SHANK3 by environmental factors suggests that SHANK3 may be a valuable biomarker for dissecting the role of gene and environment interaction in the etiology of ASD (show ARSD Antibodies).

  10. our results suggested that this commonly genetic variant in SHANK3 gene strikingly decreased the risk of ism spectrum disorder in China.

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. Cortical neurons cultured on MEAs displayed a rich repertoire of spontaneous firing, and Shank3 deletion led to reduced firing. MEA (show MEA1 Antibodies) recordings revealed electric phenotypes that displayed altered excitation and inhibition in the network lacking Shank3.

  2. "reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1 (show SHANK1 Antibodies)-/- and Shank3B-/- mice, was due to a reduction in Pvalb (show PVALB Antibodies) mRNA and PV protein.

  3. post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7 (show LILRB1 Antibodies), miR (show MLXIP Antibodies)-34a, and miR (show MLXIP Antibodies)-504, is reported.

  4. differential Shank3 mRNA stability and SHANK1 (show SHANK1 Antibodies)/2 upregulation in mutant mice with Shank3 mutations linked to autism spectrum disorder and schizophrenia

  5. social deficits and NMDAR (show GRIN1 Antibodies) hypofunction are rescued by inhibiting cofilin (show CFL1 Antibodies) or activating Rac1 in Shank3-deficient mice

  6. results reveal the profound effect of post-developmental activation of Shank3 expression on neural function, and demonstrate a certain degree of continued plasticity in the adult diseased brain

  7. Since mutations in all three human SHANK (show SHANK2 Antibodies) genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank (show SHANK2 Antibodies) mutant mice serve as corresponding in vivo model systems--{REVIEW}

  8. This study demonstrated that Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits in mice.

  9. results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain-independent

  10. prenatal zinc deficiency as a risk factor for autism spectrum disorder may unfold through the deregulation of zinc-binding ProSAP/Shank (show SHANK2 Antibodies) family members

SHANK3 Antigen Profile

Protein Summary

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

Gene names and symbols associated with SHANK3

  • SH3 and multiple ankyrin repeat domains 3 (SHANK3) antibody
  • SH3 and multiple ankyrin repeat domains protein 3 (shank3) antibody
  • SH3 and multiple ankyrin repeat domains 3 (Shank3) antibody
  • SH3/ankyrin domain gene 3 (Shank3) antibody
  • AI841104 antibody
  • DEL22q13.3 antibody
  • Prosap2 antibody
  • PSAP2 antibody
  • SCZD15 antibody
  • Shank3b antibody
  • SPANK-2 antibody

Protein level used designations for SHANK3

SH3 and multiple ankyrin repeat domains 3 , SH3 and multiple ankyrin repeat domains protein 3-like , SH3 and multiple ankyrin repeat domains protein 3 , proline rich synapse associated protein 2 , shank postsynaptic density protein , SH3/ankyrin domain gene 3 , SPANK-2 , Shank postsynaptic density protein 3a , proline-rich synapse-associated protein 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 1 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 3 , SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1 , proSAP2

GENE ID SPECIES
100056993 Equus caballus
100447919 Pongo abelii
100482495 Ailuropoda melanoleuca
793484 Danio rerio
85358 Homo sapiens
59312 Rattus norvegicus
474456 Canis lupus familiaris
512428 Bos taurus
58234 Mus musculus
Selected quality suppliers for anti-SHANK3 (SHANK3) Antibodies
Did you look for something else?