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SHANK-Associated RH Domain Interacting Protein (SHARPIN) ELISA Kits

directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank. Additionally we are shipping SHARPIN Antibodies (50) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SHARPIN 106025 Q91WA6
SHARPIN 81858 Q9H0F6
SHARPIN 81859 Q9EQL9
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Top SHARPIN ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 11 to 13 Days
$875.60
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Rat
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$875.60
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Mouse
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$875.60
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Cow
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$1,029.60
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More ELISA Kits for SHARPIN Interaction Partners

Mouse (Murine) SHANK-Associated RH Domain Interacting Protein (SHARPIN) interaction partners

  1. Study identifies a role for SHARPIN in TCR signaling whereby it maintains immunological homeostasis and tolerance by regulating Treg cells.

  2. severity of the esophagitis was not affected by crossing SHARPIN-deficient mice with lymphocyte-deficient Rag1 (show RAG1 ELISA Kits) null mice

  3. Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.

  4. Data indicate that genetic ablation of caspase-1 (show CASP1 ELISA Kits) and -11 from cpdm mice significantly reduced skin inflammation in sharpin-deficient mice.

  5. Our results suggest that SHARPIN plays a significant role in skeletal homeostasis and that this role is strongly regulated through TNF (show TNF ELISA Kits) pathways.

  6. Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF (show TNF ELISA Kits)-induced apoptosis.

  7. Tnfr1 (show TNFRSF1A ELISA Kits), but not Tnfr2 (show TNFRSF1B ELISA Kits), deficiency suppresses inflammation in sharpin deficient mice.

  8. SHARPIN is required for optimal NLRP3 (show NLRP3 ELISA Kits) inflammasome activation.

  9. Sharpin deficiency results in chronic proliferative dermatitis/ autoinflammatory disease in the absence of B and T lymphocytes and IL4 (show IL4 ELISA Kits)/IL13 (show IL13 ELISA Kits) signaling.

  10. SHARPIN controls lymphocyte migration by endogenously maintaining LFA-1 (show ITGAL ELISA Kits) inactive to allow adjustable detachment of the uropods in polarized cells.

Human SHANK-Associated RH Domain Interacting Protein (SHARPIN) interaction partners

  1. Data show that SHANK-associated RH domain interacting protein (SHARPIN) gene expression in breast cancer patients predicts clinical outcomes.

  2. the roles of SHARPIN in inhibiting integrin activity and supporting linear ubiquitination are (molecularly) distinct.

  3. progesterone significantly reduced SIPL1 mRNA and protein expression in MCF7 cells. As progesterone enhances breast cancer tumorigenesis in context dependent manner, inhibition of SIPL1 expression may contribute to progesterone's non-tumorigenic function

  4. SIPL1 binds PTEN and enhances PTEN polyubiquitination.

  5. Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF (show TNF ELISA Kits)-induced apoptosis.

  6. SIPL1 promotes AKT (show AKT1 ELISA Kits) activation by decreasing the amount of PTEN protein in CHO (show COL11A1 ELISA Kits)-K1 cells.

  7. SHARPIN controls lymphocyte migration by endogenously maintaining LFA-1 (show ITGAL ELISA Kits) inactive to allow adjustable detachment of the uropods in polarized cells.

  8. crystals of SHARPIN belonged to the primitive tetragonal space group P4(3)2(1)2, with unit-cell parameters a = b = 61.55, c = 222.81 A

  9. the crystal structure of the N-terminal portion of SHARPIN, which adopts the highly conserved pleckstrin (show PLEK ELISA Kits) homology superfold that is often used as a scaffold to create protein interaction modules

  10. SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations.

SHARPIN Antigen Profile

Antigen Summary

directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank

Gene names and symbols associated with SHARPIN

  • SHANK-associated RH domain interacting protein (Sharpin) antibody
  • SHANK-associated RH domain interactor (SHARPIN) antibody
  • SHANK-associated RH domain interactor (Sharpin) antibody
  • 0610041B22Rik antibody
  • AW121341 antibody
  • Conneck1 antibody
  • cpdm antibody
  • RBCKL1 antibody
  • SIPL1 antibody

Protein level used designations for SHARPIN

mSIPL1 , protein kinase C-interacting protein RBCC like 1 , shank-associated RH domain-interacting protein , shank-interacting protein-like 1 , sharpin , hSIPL1 , SHANK-associated RH domain interacting protein , shank-interacting protein

GENE ID SPECIES
106025 Mus musculus
81858 Homo sapiens
81859 Rattus norvegicus
512499 Bos taurus
475122 Canis lupus familiaris
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