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SMOC1 encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Additionally we are shipping SMOC1 Antibodies (34) and SMOC1 Kits (1) and many more products for this protein.
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Human SMOC1 Protein expressed in Human Cells - ABIN2004985
Vannahme, Smyth, Miosge, Gösling, Frie, Paulsson, Maurer, Hartmann: Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. in The Journal of biological chemistry 2002
SMOC binds to Pro-EGF (show EGF Proteins), but does not induce Erk (show EPHB2 Proteins) phosphorylation via the EGFR (show EGFR Proteins).
IL-17A (show IL17A Proteins) but not IL-22 (show IL22 Proteins) suppresses the replication of hepatitis B virus by inducing the expression of MxA (show MX1 Proteins) and OAS.
SMOC1 provides a link between prenatal hormone exposure and digit ratio.
Homozygosity mapping and subsequent targeted mutation analysis of a locus on 14q24.2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families with Waardenburg Anophthalmia syndrome.
The present study thus identified SPARC related modular calcium binding 1 as a new cancer-associated protein capable of interacting with tenascin-C (show TNC Proteins) in vitro
these findings indicate that SMOC1/Smoc1 is essential for ocular and limb development in both humans and mice.
Waardenburg anophthalmia syndrome is genetically heterogeneous; a second was locus found on chromosome 14, and mutations in SMOC1 were shown also cause this syndrome.
Analyzed the secretory protein profiles of BMSCs grown in osteogenic medium (OSM (show OSM Proteins)) and identified SPARC-related modular calcium-binding protein 1 (SMOC1), a member of the SPARC (show SPARC Proteins) family, as a regulator of osteoblast differentiation of BMSCs.
isolation of the novel gene SMOC-1 encoding a secreted modular protein containing an EF-hand calcium-binding domain; localization within basement membranes in kidney and skeletal muscle and expression in the zona pellucida surrounding the oocyte
SMOC-1 is of physiological interest because it codes a secreted glycoprotein with five domains, each containing regions homologous to those on other proteins that mediate cell-matrix interactions.
SMOC1 is an activin-like kinase antagonist produced by endothelial cells that tips TGF-beta (show TGFB1 Proteins) signalling towards ALK1 (show ACVRL1 Proteins) activation
The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties.
SMOC1 and SMOC2 (show SMOC2 Proteins) may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
expression of SMOC-1 examined in the early embryo day 7, as well as in following embryonic stages on days 12, 14, 16 & 18; broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis
This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SPARC-related modular calcium binding protein 1
, SPARC-related modular calcium-binding protein 1
, SPARC related modular calcium binding 1
, secreted modular calcium-binding protein 1
, secreted modular calcium-binding 1
, SPARC-related gene protein
, SPARC-related protein
, secreted modular calcium binding protein 1