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SRY (Sex Determining Region Y)-Box 18 Proteins (SOX18)

SOX18 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX18 Antibodies (39) and SOX18 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX18 54345 P35713
Rat SOX18 SOX18 311723  
SOX18 20672 P43680
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Top SOX18 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

SOX18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 18 (SOX18) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 18 (SOX18) interaction partners

  1. The downregulation of SOX18 was found to significantly inhibit cell adhesion and invasion.

  2. NKD2 (show NKD2 Proteins) inhibits SOX18 and MMP-2,7,9 expression and suppresses BGC823 cell xenograft growth. NKD2 (show NKD2 Proteins) methylation may serve as a poor prognostic and chemo-sensitive marker in human gastric cancer. NKD2 (show NKD2 Proteins) impedes gastric cancer metastasis by inhibiting SOX18.

  3. GLI1 (show GLI1 Proteins) and GLI2, but not GLI3 (show GLI3 Proteins) are involved in the regulation of SOX18 gene expression in cervical carcinoma cell lines.

  4. we demonstrated that upregulation of SOX18 was associated with a poor outcome in hepatocellular carcinoma patients

  5. The genetic finding of a pathogenic SOX18 mutation enabled the diagnosis of the rare hypotrichosis-lymphedema-telangiectasia syndrome in our patient.

  6. A new, autosomal dominant condition combining hypotrichosis-lymphedema-telangiectasia syndrome with renal defects is associated with a novel truncating mutation in the SOX18 gene.

  7. SOX18 may be involved in the progression of Non small cell lung cancer.

  8. Data suggest that SOX18 transcription factor expression may serve as a marker for a poor prognosis in invasive ductal breast carcinoma.

  9. The repression of Sox18 and its target genes may lead to altered formation of vessels in inflamed settings.

  10. of the 679 gastric cancer cases, 177 (26.1%) were positive for SOX 18 expression in their tumor stroma, and the frequencies of both lymphovascular invasion and lymph node metastases were higher in the SOX 18 positive than in the negative group.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 18 (SOX18) interaction partners

  1. Here we demonstrate that VEGF (show VEGFA Proteins)-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype

Mouse (Murine) SRY (Sex Determining Region Y)-Box 18 (SOX18) interaction partners

  1. combined deletion of Sox7 (show SOX7 Proteins), Sox17 (show SOX17 Proteins), and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (show SOX17 Proteins) allele largely restores arterial identity

  2. Sox18 genetically interacts with VegfC (show VEGFC Proteins) to regulate lymphangiogenesis in Zebrafish.

  3. SOX18 induction is a key step in mediating tumor lymphangiogenesis and metastasis

  4. Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton.

  5. Results indicate that Sox17 (show SOX17 Proteins) and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development.

  6. These result can explain previously controversial data on the functional consequences of Sox18 mutations in mice and humans.

  7. Sox17 (show SOX17 Proteins)/Sox18 double-null embryos showed more severe defects in formation of anterior dorsal aorta and head/cervical microvasculature, and in some cases, aberrant differentiation of endocardial cells and defective fusion of the endocardial tube

  8. findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies

  9. SOX18 plays role in the vascular dysfunction in hypotrichosis-lymphedema-telangiectasia syndrome.

  10. SOX7 (show SOX7 Proteins) and SOX17 (show SOX17 Proteins) are not normally expressed during lymphatic development, excluding a conventional redundancy mechanism with SOX18. Instead, these genes are activated specifically in the absence of SOX18 function, and only in certain strains.

SOX18 Protein Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.

Gene names and symbols associated with SOX18

  • SRY (sex determining region Y)-box 18 (SOX18)
  • SRY (sex determining region Y)-box 18 (Sox18)
  • SRY-box containing gene 18 (Sox18)
  • AI385749 protein
  • HLTS protein
  • Ra protein
  • Ragl protein

Protein level used designations for SOX18

SRY-box 18 , transcription factor SOX-18 , SRY-box containing gene 18 , Sry-related HMG-box gene 18 , ragged

54345 Homo sapiens
100049667 Sus scrofa
519439 Bos taurus
311723 Rattus norvegicus
20672 Mus musculus
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