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Sad1 and UNC84 Domain Containing 1 Proteins (SUN1)

SUN1 is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. Additionally we are shipping SUN1 Antibodies (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUN1 23353 O94901
SUN1 77053 Q9D666
Rat SUN1 SUN1 360773  
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Top SUN1 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SUN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Sad1 and UNC84 Domain Containing 1 (SUN1) Interaction Partners

Caenorhabditis elegans (C. elegans) Sad1 and UNC84 Domain Containing 1 (SUN1) interaction partners

  1. POT-1 (show POT1 Proteins) has a role in anchoring telomeres through SUN-1 at the nuclear periphery.

  2. This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover

  3. The dynamics of matefin/SUN-1 aggregates remained unchanged throughout leptonene/zygotene, despite the progression of pairing.

  4. Data show that ZYG-12 is immobile at the outer nuclear membrane and that SUN-1 is sufficient to localize ZYG-12 in cells.

  5. Data suggest that the properties of the nuclear envelope are altered during the time window when homologs are sorted and Matefin/SUN-1 aggregates form, thereby controling the movement, homologous pairing and interhomolog recombination of chromosomes.

Human Sad1 and UNC84 Domain Containing 1 (SUN1) interaction partners

  1. Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2 (show SUN2 Proteins), as well as the Sec61 (show SEC61A1 Proteins) translocon complex.

  2. SUN1 plays a role in hnRNP (show HNRNPC Proteins)-involved mRNA export.

  3. An important role for SUN1 and SUN2 (show SUN2 Proteins) in muscle disease pathogenesis.

  4. these data support a model whereby mitotic phosphorylation of SUN1 disrupts interactions with nucleoplasmic binding partners, promoting disassembly of the nuclear lamina and, potentially, its chromatin interactions

  5. The Caenorhabditis elegans lamin, LMN-1, is required for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84.

  6. Results highlight the interactions at the nuclear envelope where mutations in the EMD (show EMD Proteins) and TMPO (show TMPO Proteins) gene in combination with mutations in SUN1 have an impact on several components of the network.

  7. Farnesylation of progerin enhances its interaction with SUN1 and reduces SUN1 mobility.

  8. Codepletion of SUN1/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles.

  9. Reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from (show LMNA Proteins) HGPS patients corrected nuclear defects and cellular senescence.

  10. These results demonstrate that the interplay between SUN1 and farnesylated prelamin A contributes to nuclear positioning in human myofibers and may be implicated in pathogenetic mechanisms.

Mouse (Murine) Sad1 and UNC84 Domain Containing 1 (SUN1) interaction partners

  1. A cell-type-specific role for Sun1 and Sun2 (show SUN2 Proteins) in nucleokinesis during cerebellar development, is reported.

  2. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.

  3. our results clearly indicate that SUN1 and SUN2 (show SUN2 Proteins), at least partially, fulfill redundant meiotic functions

  4. Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, participate in cone nuclei positioning.

  5. Sun1 has a role in DNA damage response.

  6. It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin (show DCTN1 Proteins) complex.

  7. These findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna (show LMNA Proteins)(-/-), LmnaDelta9 mice, models for Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria disorders.

  8. Syne-2 (show SYNE2 Proteins), SUN1 and SUN2 (show SUN2 Proteins) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.

  9. perturbations in lamin A (show LMNA Proteins)-SUN1 and SUN2 (show SUN2 Proteins) protein interactions may underlie the opposing effects of EDMD (show EMD Proteins) and HGPS (show LMNA Proteins) mutations on nuclear and cellular mechanics

  10. The Sun1 serves as a 'structural bridge' connecting the nuclear interior with the actin cytoskeleton.

SUN1 Protein Profile

Protein Summary

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with SUN1

  • Protein SUN-1 (sun-1)
  • Sad1 and UNC84 domain containing 1 (SUN1)
  • Sad1 and UNC84 domain containing 1 (Sun1)
  • 4632417G13Rik protein
  • 5730434D03Rik protein
  • mKIAA0810 protein
  • Unc84a protein

Protein level used designations for SUN1

SUN domain-containing protein 1 , Sad1 unc-84 domain protein 1 , protein unc-84 homolog A , sad1/unc-84 protein-like 1 , unc-84 homolog A

GENE ID SPECIES
179802 Caenorhabditis elegans
23353 Homo sapiens
480806 Canis lupus familiaris
77053 Mus musculus
360773 Rattus norvegicus
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