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anti-Salvador Homolog 1 (Drosophila) (SAV1) Antibodies

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping SAV1 Proteins (5) and SAV1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SAV1 60485 Q9H4B6
SAV1 64010 Q8VEB2
SAV1 299116 A4V8B4
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Top anti-SAV1 Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB SAV1 monoclonal antibody (M04), clone 3A10. Western Blot analysis of SAV1 expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SAV1 on HeLa cell (antibody concentration 60 µg/mL). SAV1 monoclonal antibody (M02), clone 3B2 Western Blot analysis of SAV1 expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Sav1 AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, IP, ELISA, WB SAV1 monoclonal antibody (M02), clone 3B2 Western Blot analysis of SAV1 expression in Hela S3 NE . Immunofluorescence of monoclonal antibody to SAV1 on HeLa cell. [antibody concentration 60 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB SAV1 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SAV1 antibody detected the SAV1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of SAV1 transfected lysate using anti-SAV1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with SAV1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of SAV1 expression in transfected 293T cell line by SAV1 MaxPab polyclonal antibody.Lane 1: SAV1 transfected lysate(44.6 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Mouse Un-conjugated ELISA, WB SAV1 monoclonal antibody (M04), clone 3A10. Western Blot analysis of SAV1 expression in Hela S3 NE . Detection limit for recombinant GST tagged SAV1 is 0.1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$493.17
Details

SAV1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine) ,
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Rat (Rattus)
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Top referenced anti-SAV1 Antibodies

  1. Human Monoclonal SAV1 Primary Antibody for IF, IP - ABIN566210 : Mardin, Lange, Baxter, Hardy, Scholz, Fry, Schiebel: Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. in Nature cell biology 2010 (PubMed)
    Show all 5 references for ABIN566210

  2. Human Monoclonal SAV1 Primary Antibody for IF, WB - ABIN394223 : Luo, Li, Yan, Li, Tao, Wang, Leng, Gardner, Judge, Li, Hu, Gong: The human WW45 protein enhances MST1-mediated apoptosis in vivo. in International journal of molecular medicine 2009 (PubMed)
    Show all 5 references for ABIN394223

  3. Human Monoclonal SAV1 Primary Antibody for WB - ABIN394202 : Callus, Verhagen, Vaux: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. in The FEBS journal 2006 (PubMed)
    Show all 5 references for ABIN394202

More Antibodies against SAV1 Interaction Partners

Human Salvador Homolog 1 (Drosophila) (SAV1) interaction partners

  1. using an Mst2 (show STK3 Antibodies) mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2 (show STK3 Antibodies)-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH.

  2. MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes.

  3. Mst2 (show STK3 Antibodies) and the Ser (show SIGLEC1 Antibodies)-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45.

  4. We also confirmed the interaction of HAX-1 (show HAX1 Antibodies) and hSav1 in mammalian cells.

  5. downregulation of SAV1 and the consequent YAP1 (show YAP1 Antibodies) activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma (show MOK Antibodies).

  6. MST (show MAP3K10 Antibodies) and hSAV act as novel co-regulators of ERalpha (show ESR1 Antibodies) and may play an important role in breast cancer pathogenesis.

  7. hSav1 interacts with HAX1 (show HAX1 Antibodies) and attenuates its protective role against apoptosis in MCF-7 breast cancer cells.

  8. a role for Salvador as a human tumor suppressor and RASSF1A (show RASSF1 Antibodies) effector and show that Salvador allows RASSF1A (show RASSF1 Antibodies) to modulate p73 (show TP73 Antibodies) independently of the hippo pathway.

  9. Study reports that two Hippo pathway components, Mst2 and the scaffold protein hSav1, directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin.

  10. hSav1 is a newly identified protein that interacts with Mst1 (show MST1 Antibodies) and augments Mst1 (show MST1 Antibodies)-mediated apoptosis.

Mouse (Murine) Salvador Homolog 1 (Drosophila) (SAV1) interaction partners

  1. Differentiation of 3T3-L1 cells was augmented by MST2 and SAV1 expression and inhibited by knockdown of MST1/2 or SAV1.

  2. In this study, they investigated epigenetic characteristics of WW45+/- mice, evaluating time-dependent changes from prior to the onset of tumorigenesis to hepatocarcinoma.

  3. show that mice with liver-specific ablation of WW45 (a homolog of Drosophila Salvador and adaptor for the Hippo kinase) manifest increased liver size and expansion of hepatic progenitor cells (oval cells) and eventually develop hepatomas.

  4. show using a conditional allele of sav1, that an adaptor that potentiates mst1 (show MST1 Antibodies) and mst2 (show STK3 Antibodies) activity is likewise required to suppress growth in the mature liver and to prevent tumor formation.

  5. While typical WW domains function as monomeric modules that recognize proline-rich sequences, by using conserved residues that are solvent-exposed on the surface of the beta-sheet, this WW domain (show DRP2 Antibodies) buries these residues in the dimer interface.

  6. Mice lacking WW45 reveal a crucial role for WW45 in cell-cycle exit and epithelial terminal differentiation.

SAV1 Antigen Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Gene names and symbols associated with SAV1

  • salvador homolog 1 (Drosophila) (SAV1) antibody
  • salvador homolog 1 (Drosophila) (Sav1) antibody
  • 1700040G09Rik antibody
  • Salv antibody
  • Sav antibody
  • WW45 antibody
  • Wwp3 antibody
  • Wwp4 antibody

Protein level used designations for SAV1

1700040G09Rik , 45 kDa WW domain protein , WW domain-containing , hWW45 , protein salvador homolog 1 , WW domain-containing protein 3 , WW domain-containing protein 4 , Salvador homolog 1 protein , rWW45

GENE ID SPECIES
60485 Homo sapiens
64010 Mus musculus
299116 Rattus norvegicus
Selected quality suppliers for anti-SAV1 (SAV1) Antibodies
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