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Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) Proteins (SGCD)

The protein encoded by SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). Additionally we are shipping SGCD Antibodies (59) and SGCD Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SGCD 6444 Q92629
SGCD 24052 P82347
Rat SGCD SGCD 497892  
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Top SGCD Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,588.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

SGCD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

Top referenced SGCD Proteins

  1. Human SGCD Protein expressed in Escherichia coli (E. coli) - ABIN1098776 : Sylvius, Duboscq-Bidot, Bouchier, Charron, Benaiche, Sébillon, Komajda, Villard: Mutational analysis of the beta- and delta-sarcoglycan genes in a large number of patients with familial and sporadic dilated cardiomyopathy. in American journal of medical genetics. Part A 2003 (PubMed)

More Proteins for Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

  1. deletion of the delta-sarcoglycan gene produced disrupted flight muscles with shortened sarcomeres and disorganized M lines

Zebrafish Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

  1. delta-sarcoglycan plays an important role in early heart and muscle development.

Human Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

  1. CC genotype of the delta-sarcoglycan gene polymorphism rs13170573 is associated with obstructive sleep apnea in the Chinese population

  2. Genetic variation at the delta-sarcoglycan locus elevates heritable sympathetic nerve activity in human twin pairs

  3. Finding questions the pathological relevance of sequence variant of the delta-sarcoglycan gene for causing familial autosomal-dominant dilated cardiomyopathy.

  4. These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport.

  5. The 5'-UTR G to C polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with hypertrophic cardiomyopathy.

  6. The limb-girdle muscular dystrophy patients with delta-sarcoglycan deficient LGMD2F do not enable an accurate prediction of the genotype.

Mouse (Murine) Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

  1. Collectively, these results confirm and extend understanding of a functional role for the dystrophin (show DMD Proteins)-glycoprotein complex in the contractile properties of airway smooth muscle and demonstrate that this results in altered lung function in vivo.

  2. Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely.

  3. Despite SGC rescue, and contrary to previous observations obtained with WT/mdx chimeras low levels of ESC incorporation were insufficient to produce histological corrections in SGdelta-KO skeletal muscle or heart.

  4. This study supports a model where dystrophin (show DMD Proteins), but not the sarcoglycans, protects the cardiac myocyte against mechanical damage.

  5. dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin (show DMD Proteins) mutant mdx (show DMD Proteins) mice is dramatically improved by skeletal muscle-specific (show EIF3K Proteins) overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1 (show ATP2A1 Proteins))

  6. delta-SG isoforms may stabilize gamma-SG (show SGCG Proteins) and microSPN in transverse tubules and sarcoplasmic reticulum membranes and this possible complex may play a role in maintenance of stable level of resting cytosolic calcium concentration in skeletal muscle.

  7. Abscence of sarcoglycan delta may be related to pathogenesis of muscular dystrophy.

  8. delta- and gamma-sarcoglycan (show SGCG Proteins) prevent vascular spasm in coronary arteries and in vascular smooth muscle

  9. a delta-sarcoglycan isoform is localized at the sarcoplasmic reticulum of mouse skeletal muscle

  10. We propose that MDPCs may be the promising progenitor cells in skeletal muscle to treat delta-sarcoglycan complex mutant cardiomyopathy.

SGCD Protein Profile

Protein Summary

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Gene names and symbols associated with SGCD

  • sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (SGCD)
  • Sarcoglycan delta (Scgdelta)
  • sarcoglycan, delta (dystrophin-associated glycoprotein) (sgcd)
  • sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (Sgcd)
  • sarcoglycan, delta (dystrophin-associated glycoprotein) (Sgcd)
  • 35DAG protein
  • 35kDa protein
  • BEST:GH21860 protein
  • CG14808 protein
  • CMD1L protein
  • CT34621 protein
  • DAGD protein
  • delta-SG protein
  • Dmel\\CG14808 protein
  • DmSCG-gammadelta protein
  • EG:4F1.1 protein
  • GH21860 protein
  • SG-delta protein
  • Sgcd protein
  • SGCDP protein
  • SGD protein
  • wu:fc49e11 protein
  • zgc:110649 protein

Protein level used designations for SGCD

sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) , CG14808-PA , CG14808-PB , CG14808-PC , CG14808-PD , Scgdelta-PA , Scgdelta-PB , Scgdelta-PC , Scgdelta-PD , delta-sarcoglycan , sarcoglycan , sarcoglycan delta , sarcoglycan, delta (dystrophin-associated glycoprotein) , 35 kDa dystrophin-associated glycoprotein , delta-SG , dystrophin associated glycoprotein, delta sarcoglycan , placental delta sarcoglycan , delta sarcoglycan , 35DAG , SG-delta , sarcoglycan, delta (35kD dystrophin-associated glycoprotein)

GENE ID SPECIES
462216 Pan troglodytes
31129 Drosophila melanogaster
324961 Danio rerio
416251 Gallus gallus
100528224 Ictalurus punctatus
6444 Homo sapiens
612079 Canis lupus familiaris
100240724 Sus scrofa
517059 Bos taurus
101837953 Mesocricetus auratus
24052 Mus musculus
497892 Rattus norvegicus
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