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SEMA5A belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Additionally we are shipping SEMA5A Antibodies (83) and SEMA5A Kits (11) and many more products for this protein.
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Sema5A is a bifunctional axon guidance cue for vertebrate motor axons in vivo. The TSR (show CFL1 Proteins) domain promotes growth of developing motor axons into the ventral myotome whereas the sema (show SEMA3B Proteins) domain mediates repulsion
De novo translocation t(5;22)(p15.3;q11.21) associated with a partial deletion of SEMA5A identified in a patient with ASD (show ARSD Proteins).
data demonstrated that elevated serum Semaphorin5A in systemic lupus erythematosus patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 (show ADAM17 Proteins) might be involved in the release of secreted Sema5A
Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described.
The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development.
Using human gastric cancer cell lines, found semaphorin 5A significantly promoted invasive & metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell.
Results suggest that a bioactive, secreted form of Sema5A-ECD (show SHFM1 Proteins) has an intriguing and potentially important role in its ability to enhance pancreatic tumour invasiveness, angiogenesis and micrometastases.
Data show that Semaphorin 5A (Sema5A) and plexin-B3 (show PLXNB3 Proteins) inhibit glioma cell invasion through Rac1 inactivation.
The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC.
Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha.
data demonstrate that the expression of SEMA5A in pancreatic cancer cells regulates tumorigenesis, growth, invasion and metastasis, and it also suggests a novel target for diagnosis and treatment of pancreatic cancer
Mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells.
The results of this study concluded that the Sema5a mice do not meet the behavioral criteria for a mouse model of autism.
Sema5A and Sema5B (show SEMA5B Proteins) inhibit retinal neurite outgrowth through PlexinA1 (show PLXNA1 Proteins) and PlexinA3 (show PLXNA3 Proteins) receptors both in vitro and in vivo.
Data reveal that Sema5A is a novel proangiogenic molecule, inducing endothelial cell proliferation and migration and inhibiting apoptosis.
development of some CNS nerves requires inhibitory sheaths to maintain integrity, this is accomplished using molecules such as Sema5A that exhibit conserved inhibitory responses in the presence of impinging signals from multiple guidance molecules.
Plexin-B3 (show PLXNB3 Proteins) is a functional receptor for semaphorin 5A
Semaphorin 5A (Sema5A) is a bifunctional guidance cue exerting both attractive and inhibitory effects on developing axons of the fasciculus retroflexus, a diencephalon fiber tract associated with limbic function.
A role of Sema5A in the remodeling of the cranial blood vessels was shown.
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
, semaphorin 5A
, sema F
, semaphorin F
, M-Sema D