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Sestrin 1 Proteins (SESN1)

SESN1 encodes a member of the sestrin family. Additionally we are shipping Sestrin 1 Antibodies (56) and Sestrin 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SESN1 27244 Q9Y6P5
SESN1 140742 P58006
SESN1 294518  
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Top Sestrin 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,358.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SESN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sestrin 1 (SESN1) Interaction Partners

Zebrafish Sestrin 1 (SESN1) interaction partners

  1. identify SESN1 as an indispensable gene for vertebrate left-right asymmetry and a new player in mediating Nodal signaling

Human Sestrin 1 (SESN1) interaction partners

  1. Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 (show CRTC2 Proteins) in appeasing low shear stress induced EC oxidative apoptosis

  2. PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans.

  3. results show that sestrins, a family of proteins whose expression is modulated by p53 (show TP53 Proteins), are required for regeneration of peroxiredoxins containing Cys (show DNAJC5 Proteins)-SO(2)H

Mouse (Murine) Sestrin 1 (SESN1) interaction partners

  1. Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.

  2. The enhanced tumor susceptibility of p53 (show TP53 Proteins)+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for standard 2-year rodent carcinogenicity assays.

  3. Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 (show TP53 Proteins) and the mTOR (show FRAP1 Proteins) signaling pathway.

Sestrin 1 (SESN1) Protein Profile

Protein Summary

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Sestrin 1 Proteins (SESN1)

  • sestrin 1 (SESN1)
  • sestrin 1 (sesn1)
  • sestrin 1 (Sesn1)
  • 1110002G11Rik protein
  • AU044290 protein
  • Pa26 protein
  • SESN1 protein
  • sesn1-A protein
  • Sest1 protein
  • sestrin-1 protein
  • XPA26 protein
  • zgc:91970 protein

Protein level used designations for Sestrin 1 Proteins (SESN1)

sestrin 1 , sestrin-1 , nuclear factor XPA26-T2 , p53 activated gene 26 , p53 regulated PA26 nuclear protein , p53 regulated Pa26 nuclear protein , p53-regulated protein PA26 , XPA26 , sestrin 1,nuclear factor XPA26-T2

GENE ID SPECIES
421766 Gallus gallus
436933 Danio rerio
462922 Pan troglodytes
481956 Canis lupus familiaris
700232 Macaca mulatta
100170187 Xenopus (Silurana) tropicalis
100174188 Pongo abelii
100601789 Nomascus leucogenys
27244 Homo sapiens
140742 Mus musculus
294518 Rattus norvegicus
538226 Bos taurus
379559 Xenopus laevis
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