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SESN1 encodes a member of the sestrin family. Additionally we are shipping Sestrin 1 Antibodies (56) and Sestrin 1 Kits (9) and many more products for this protein.
Showing 6 out of 6 products:
identify SESN1 as an indispensable gene for vertebrate left-right asymmetry and a new player in mediating Nodal signaling
Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 (show CRTC2 Proteins) in appeasing low shear stress induced EC oxidative apoptosis
PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans.
results show that sestrins, a family of proteins whose expression is modulated by p53 (show TP53 Proteins), are required for regeneration of peroxiredoxins containing Cys (show DNAJC5 Proteins)-SO(2)H
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
The enhanced tumor susceptibility of p53 (show TP53 Proteins)+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for standard 2-year rodent carcinogenicity assays.
Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 (show TP53 Proteins) and the mTOR (show FRAP1 Proteins) signaling pathway.
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, nuclear factor XPA26-T2
, p53 activated gene 26
, p53 regulated PA26 nuclear protein
, p53 regulated Pa26 nuclear protein
, p53-regulated protein PA26
, sestrin 1,nuclear factor XPA26-T2