Sestrin 2 Proteins (SESN2)

SESN2 encodes a member of the sestrin family of PA26-related proteins. Additionally we are shipping Sestrin 2 Antibodies (53) and Sestrin 2 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SESN2 83667 P58004
SESN2 230784 P58043
SESN2 502988  
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Top Sestrin 2 Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Mouse S tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

SESN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
Rat (Rattus)

More Proteins for Sestrin 2 (SESN2) Interaction Partners

Human Sestrin 2 (SESN2) interaction partners

  1. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.

  2. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8 (show MAPK8 Proteins)-JUN (show JUN Proteins)-dependent transcriptional induction of SESN2

  3. The results suggest that SESN2 increases degradation of HIF-1A (show HIF1A Proteins) via AMPK (show PRKAA1 Proteins)-PHD (show PDC Proteins) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.

  4. simple analysis of the reported "apo (show C9orf3 Proteins)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.

  5. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (show SPR Proteins)) of affinity purified sesn1 (show SESN1 Proteins) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (show SESN1 Proteins) and sesn2 have a predominant a-helical structure.

  6. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma

  7. The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (show ATF4 Proteins).

  8. Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (show TXNRD1 Proteins) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.

  9. SESN2-AMPK (show PRKAA1 Proteins) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.

  10. Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.

Mouse (Murine) Sestrin 2 (SESN2) interaction partners

  1. sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 (show NLRP3 Proteins) activation in macrophages

  2. SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.

  3. Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (show PRKAA1 Proteins) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.

  4. p53 (show TP53 Proteins)-dependent coordination with SESN2 regulates AMPK (show PRKAA1 Proteins) and mTORC1 signaling and controls parturition timing

  5. Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (show INS Proteins) signaling through the activation of AMPK (show PRKAA1 Proteins) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (show INS Proteins) sensitivity and glucose metabolism via AMPK (show PRKAA1 Proteins)-dependent autophagic activation.

  6. Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (show HMOX1 Proteins)/Sesn2 signaling pathway.

  7. suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (show JUN Proteins), Nrf2 (show NFE2L2 Proteins), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity

  8. an AMPK (show PRKAA1 Proteins)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.

  9. Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.

  10. Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) scaffold to initiate AMPK (show PRKAA1 Proteins) activation during ischemic insults

Sestrin 2 (SESN2) Protein Profile

Protein Summary

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

Gene names and symbols associated with Sestrin 2 Proteins (SESN2)

  • sestrin 2 (SESN2)
  • sestrin 2 (Sesn2)
  • sestrin 2 L homeolog (sesn2.L)
  • sestrin 2 (sesn2)
  • hi95 protein
  • MGC81239 protein
  • RGD1566319 protein
  • ses2 protein
  • SESN2 protein
  • sest2 protein
  • Sestrin-2 protein

Protein level used designations for Sestrin 2 Proteins (SESN2)

hypoxia induced gene 95 , sestrin-2 , sestrin 2 , sestrin-2-like

83667 Homo sapiens
230784 Mus musculus
414641 Xenopus laevis
469167 Pan troglodytes
487335 Canis lupus familiaris
509863 Bos taurus
716904 Macaca mulatta
733499 Xenopus (Silurana) tropicalis
100056552 Equus caballus
100172219 Pongo abelii
100353543 Oryctolagus cuniculus
100397149 Callithrix jacchus
100469808 Ailuropoda melanoleuca
100592235 Nomascus leucogenys
502988 Rattus norvegicus
100719606 Cavia porcellus
100149745 Danio rerio
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