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SESN2 encodes a member of the sestrin family of PA26-related proteins. Additionally we are shipping Sestrin 2 Antibodies (53) and Sestrin 2 Kits (21) and many more products for this protein.
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There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.
isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8 (show MAPK8 Proteins)-JUN (show JUN Proteins)-dependent transcriptional induction of SESN2
The results suggest that SESN2 increases degradation of HIF-1A (show HIF1A Proteins) via AMPK (show PRKAA1 Proteins)-PHD (show PDC Proteins) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
simple analysis of the reported "apo (show C9orf3 Proteins)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.
Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (show SPR Proteins)) of affinity purified sesn1 (show SESN1 Proteins) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (show SESN1 Proteins) and sesn2 have a predominant a-helical structure.
The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma
The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (show ATF4 Proteins).
Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (show TXNRD1 Proteins) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.
SESN2-AMPK (show PRKAA1 Proteins) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.
Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.
sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 (show NLRP3 Proteins) activation in macrophages
SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (show PRKAA1 Proteins) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
p53 (show TP53 Proteins)-dependent coordination with SESN2 regulates AMPK (show PRKAA1 Proteins) and mTORC1 signaling and controls parturition timing
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (show INS Proteins) signaling through the activation of AMPK (show PRKAA1 Proteins) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (show INS Proteins) sensitivity and glucose metabolism via AMPK (show PRKAA1 Proteins)-dependent autophagic activation.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (show HMOX1 Proteins)/Sesn2 signaling pathway.
suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (show JUN Proteins), Nrf2 (show NFE2L2 Proteins), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity
an AMPK (show PRKAA1 Proteins)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Proteins) or TSC2. Surprisingly, when coexpressed with a GTP (show AK3 Proteins)-bound constitutively active form of RagB (show RRAGB Proteins) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) scaffold to initiate AMPK (show PRKAA1 Proteins) activation during ischemic insults
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
hypoxia induced gene 95
, sestrin 2