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Sex Determining Region Y Proteins (SRY)

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. Additionally we are shipping Sex Determining Region Y Antibodies (61) and Sex Determining Region Y Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SRY SRY 21674 Q05738
Human SRY SRY 6736 Q05066
Rat SRY SRY 25221  
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Top Sex Determining Region Y Proteins at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Akodon azarae His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast REACT_Eurasian badger His tag   1 mg Log in to see 56 to 66 Days
$2,035.00
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,035.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,240.33
Details
Yeast Phocoenoides phocoena His tag   1 mg Log in to see 56 to 66 Days
$2,473.17
Details

SRY Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human ,
,
Rat (Rattus)

Top referenced Sex Determining Region Y Proteins

  1. Human SRY Protein expressed in Wheat germ - ABIN1321373 : Holt, Zhang, Binia, Dixon, Vandiedonck, Cookson, Knight, Moffatt: Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). in The Journal of allergy and clinical immunology 2011 (PubMed)

More Proteins for Sex Determining Region Y (SRY) Interaction Partners

Rabbit Sex Determining Region Y (SRY) interaction partners

Pig (Porcine) Sex Determining Region Y (SRY) interaction partners

  1. The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.

  2. New insights into SRY regulation through identification of 5' conserved sequence are reported.

Mouse (Murine) Sex Determining Region Y (SRY) interaction partners

  1. our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.

  2. Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.

  3. Sry can be replaced by transgenic activation of its downstream target Sox9 (show SOX9 Proteins). This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.

  4. SRY binds to various ovarian differentiation genes and represses their activation through WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  5. The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis

  6. Studies indicate that in most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation.

  7. disprove the hypothesis that the conserved HMG (show SSRP1 Proteins) box domain is the only functional domain of Sry, and highlight an evolutionary paradox whereby mouse Sry has evolved a novel bifunctional module to activate Sox9 (show SOX9 Proteins) directly

  8. this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.

  9. Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty.

  10. 70-kDa heat shock cognate protein hsc70 (show HSPA8 Proteins) mediates calmodulin (show Calm2 Proteins)-dependent nuclear import of the sex-determining factor SRY.

Human Sex Determining Region Y (SRY) interaction partners

  1. SRY is involved in the maintenance of cancer stem-like characteristics through OCT4 (show POU5F1 Proteins).

  2. The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender

  3. These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male

  4. The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis

  5. Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET (show RET Proteins) gene by competing with SOX10 (show SOX10 Proteins) for its interaction with PAX3 (show PAX3 Proteins) and NKX2-1 (show NKX2-1 Proteins) repressing their transcriptional expression and RET's as well.

  6. High levels of SRY expression correlated with cancer progression and poor HCC (show FAM126A Proteins) patient survival. However, high SRY levels are not significantly correlated with HCC (show FAM126A Proteins) sex bias.

  7. Findings demonstrate that the folding, trafficking, and gene-regulatory function of testis-determining factor SRY requires an invariant aromatic "buttress" beneath its specific DNA-bending surface.

  8. Overall, these results indicated that the main mechanism of sex reversal are not associated with mutations in the coding regions of SOX9 (show SOX9 Proteins) and DAX1 (show NR0B1 Proteins) or copy number variations of SOX9 (show SOX9 Proteins), which is consistent with results of previous studies.

  9. Data suggest that sex-determining region Y protein SRY upregulation after dopamine cell injury is initially a protective response in males, but diminishes with gradual loss in dopamine cells.

  10. A proximal promoter construct for the MAS (show MAS1 Proteins) gene was repressed by the SOX (show PIPOX Proteins) [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2 (show SOX2 Proteins), SOX3 (show SOX3 Proteins) and SOX14 (show SOX14 Proteins), of which SRY is known to interact with the KRAB domain.

Cow (Bovine) Sex Determining Region Y (SRY) interaction partners

  1. analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus

  2. New insights into SRY regulation through identification of 5' conserved sequence are reported.

Horse (Equine) Sex Determining Region Y (SRY) interaction partners

  1. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.

Sex Determining Region Y (SRY) Protein Profile

Protein Summary

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome)\; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.

Gene names and symbols associated with Sex Determining Region Y Proteins (SRY)

  • sex determining region Y (SRY)
  • sex determining region of Chr Y (Sry)
  • sex determining region Y (Sry)
  • SRXX1 protein
  • SRXY1 protein
  • SRY protein
  • Sry1 protein
  • Sry3BI protein
  • SRYGENE protein
  • TDF protein
  • TDY protein

Protein level used designations for Sex Determining Region Y Proteins (SRY)

sex determining region Y , sex-determining region Y protein , testis determining-Y , testis-determining factor , essential protein for sex determination in human males , sex-determining region on Y , testis-determining factor on Y , HMG box transcription factor Sry1 , HMG box transcription factor Sry3BI , Testis determining locus , sex determining region of Chr Y , sex determining region on Y , sex determining factor Y , sex-determining region of the Y-chromosome , sex determining region Y protein , sex-determining protein

GENE ID SPECIES
100328958 Oryctolagus cuniculus
100625818 Sus scrofa
21674 Mus musculus
6736 Homo sapiens
25221 Rattus norvegicus
280931 Bos taurus
493758 Felis catus
100033824 Equus caballus
407740 Sus scrofa
100529253 Ovis aries
574155 Macaca mulatta
449510 Pan troglodytes
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