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Neu3 product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Additionally we are shipping Neu3 Proteins (7) and many more products for this protein.
Showing 10 out of 13 products:
Human Monoclonal Neu3 Primary Antibody for WB - ABIN1449196
Nomura, Tamada, Miyagi, Suzuki, Taira, Suzuki, Susumu, Irimura, Aoki: Expression of NEU3 (plasma membrane-associated sialidase) in clear cell adenocarcinoma of the ovary: its relationship with T factor of pTNM classification. in Oncology research 2007
Show all 4 references for ABIN1449196
findings implicate NEU3 as a potential biomarker of insulin (show INS Antibodies) sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.
NEU3 regulates the detergent resistant membrane ganglioside content.
NEU3 up-regulation stimulates the EGF receptor (show EGFR Antibodies) signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha (show HIF1A Antibodies)), resulting in a final increase of cell survival and proliferation.
NEU3 plays an important role in inflammation-dependent tumor development
Data indicate that sialidases Neu1 (show NEURL Antibodies) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.
The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step.
NEU3 participates in the control of insulin (show INS Antibodies) signaling via modulation of gangliosides and interaction with Grb2 (show GRB2 Antibodies)
NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility.
Reduction of 70% of the plasma membrane-associated sialidase Neu3 activity caused neurite elongation in Neuro2a murine neuroblastoma (show ARHGEF16 Antibodies) cells.
findings suggest that the Neu3 gene represents a physiological modulator of VSMC responses that may contribute to plaque instability in atherosclerosis.
findings identify NEU3 as a participant in head and neck squamous cell carcinoma progression
Besides the already reported indirect EGFR (show EGFR Antibodies) activation through GM3 (show GRM6 Antibodies), sialidase NEU3 could also play a role on EGFR (show EGFR Antibodies) activation through its desialylation.
NEU3 promotes anchorage-independent growth and in vivo tumorigenicity.
In the plasma membrane, NEU3 has a role in endocytosis and protein binding at the cell surface.
Results indicate an essential contribution of NEU3 to tumorigenic potential through maintenance of stem-like characteristics of colon cancer cells by regulating Wnt (show WNT2 Antibodies) signaling at the receptor level.
The results provide strong evidence that the serum sialidase is, in fact, NEU3, and this subtype may, therefore, be a potential utility for novel diagnosis of human cancers
Studies indicate that ganglioside-specific sialidase NEU3 cleaves sialic acids preferentially from gangliosides.
Weak anchorage of NEU1 (show NEU1 Antibodies) and NEU3 to the plasma membrane and their loss during erythrocyte life could be a tool to preserve the cellular sialic acid content to avoid early aging of erythrocyte and processes of cell aggregation in the capillaries.
NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK (show PTK2 Antibodies)/AKT (show AKT1 Antibodies) signaling and demonstrate its crucial role in renal cell carcinomas malignancy.
Data indicate that sialidases Neu1 (show NEU1 Antibodies) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.
, Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3)
, ganglioside sialidase
, membrane sialidase
, neuraminidase 3