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Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 Proteins (SLC15A1)

SLC15A1 encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. Additionally we are shipping SLC15A1 Antibodies (61) and SLC15A1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC15A1 6564 P46059
SLC15A1 56643 Q9JIP7
Rat SLC15A1 SLC15A1 117261 P51574
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Top SLC15A1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC15A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) Interaction Partners

Pig (Porcine) Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. PepT1 mRNA expression in the distal jejunum increased gradually with age in suckling Tibetan piglet

Human Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. PEPT1 overexpression is associated with pancreatic cancer.

  2. Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.

  3. Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1.

  4. miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.

  5. OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane

  6. The PEPT1 rs2297322 single-nucleotide polymorphism was not associated with inflammatory bowel disease susceptibility in our German cohort.

  7. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, could play a crucial role in cell-to-cell communication during colitis

  8. The present review summarizes the recent knowledge on the factors modulating PEPT1 expression/function in Caenorhabditis elegans, Danio rerio, Mus (show TRPV6 Proteins) musculus and Homo sapiens, with focus on dietary ingredients, transcription factors and modulators.[review]

  9. promoter constructs were generated and cotransfected with an Nrf2 (show GABPA Proteins) expression plasmid

  10. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.

Mouse (Murine) Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid

  2. Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.

  3. Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.

  4. miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.

  5. PEPT1 expression is reduced during intestinal inflammation and PEPT1 is not required for muramyl dipeptide-induced immune response.

  6. Data indicate that peroxisome proliferator-activated receptor-alpha (PPARalpha (show PPARA Proteins)) activated the intestinal expression of Slc15a1 mRNA during the light period, and protein levels of PepT1 peaked before the start of the dark phase.

  7. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.

  8. PepT1 deletion reduced the area under the plasma concentration-time profile (AUC0-120) of cefadroxil by 10-fold, the maximum plasma concentration (Cmax) by 17.5-fold, and increased the time to reach a maximum plasma concentration (Tmax) by 3-fold.

  9. A critical role of intestinal PepT1 in improving the rate and extent of oral absorption for valacyclovir.

  10. PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis.

Rabbit Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2.

  2. SPAK is a powerful regulator of peptide transporters PEPT1 and PEPT2

  3. Appropriate amino acid substitutions of Arg(282) and Asp (show ASIP Proteins)(341) change the properties of PepT1 in a way that confirms that these parts of the protein act as an electrostatic gate in the transport process.

  4. Report PepT1 kinetics in vitro and using computer simulated kinetic models.

  5. The role of conserved tyrosines in the transmembrane domains (TMDs) of rabbit PepT1 as predicted by hydropathy plots, was investigated.

  6. Mutation of rabbit PepT1 arginine282 R282E- and R282D-PepT1 showed an increased charge:peptide stoichiometry over the wild-type 1:1 ratio for the neutral dipeptide Gly-l-Gln, measured using two-electrode voltage clamp.

  7. Report substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.

Zebrafish Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. These results suggest that PepT1 may be a contributing mechanism to compensatory growth that could influence cholecystokinin (show CCK Proteins) secretion and gastrin-releasing peptide (show GRP Proteins) and ghrelin (show GHRL Proteins) activity.

  2. Report PepT1 kinetics in vitro and using computer simulated kinetic models.

  3. PEPT1 maximal transport rates unexpectedly increase at alkaline extracellular pH; pept1 is highly expressed in the proximal intestine since day 4 post-fertilisation, preceding functional maturation of the gut (show GUSB Proteins)

SLC15A1 Protein Profile

Protein Summary

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.

Gene names and symbols associated with SLC15A1

  • solute carrier family 15 (oligopeptide transporter), member 1 (SLC15A1)
  • solute carrier family 15 (oligopeptide transporter), member 1 (slc15a1)
  • solute carrier family 15 (oligopeptide transporter), member 1 (LOC100219866)
  • solute carrier family 15 (oligopeptide transporter), member 1 (Slc15a1)
  • solute carrier family 15 (oligopeptide transporter), member 1b (slc15a1b)
  • D630032F02 protein
  • fd47f07 protein
  • HPECT1 protein
  • HPEPT1 protein
  • PECT1 protein
  • PEPT-1 protein
  • Pept1 protein
  • slc15a1 protein
  • wu:fd47f07 protein

Protein level used designations for SLC15A1

peptide transporter 1 , solute carrier family 15 member 1 , solute carrier family 15 (oligopeptide transporter), member 1 , proton-dependent dipeptide transporter PEPT1 , solute carrier family 15 member 1-like , Caco-2 oligopeptide transporter , intestinal H+/peptide cotransporter , macrophage oligopeptide transporter PEPT1 , oligopeptide transporter, small intestine isoform , intestinal H(+)/peptide cotransporter , intestinal peptide transporter PEPT1 , proton-coupled dipeptide cotransporter , peptide transporter PepT1 , proton-dependent gastrointestinal peptide transporter 1 , pineal gland-specific PEPT1 , proton-coupled peptide cotransporter PepT1

GENE ID SPECIES
397624 Sus scrofa
467307 Pan troglodytes
574257 Macaca mulatta
100145353 Xenopus (Silurana) tropicalis
100450526 Pongo abelii
100565958 Anolis carolinensis
100582457 Nomascus leucogenys
100219866 Taeniopygia guttata
6564 Homo sapiens
56643 Mus musculus
378789 Gallus gallus
521181 Bos taurus
117261 Rattus norvegicus
403561 Canis lupus familiaris
100009186 Oryctolagus cuniculus
793301 Danio rerio
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