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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Kits (4) and Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Proteins (4) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal SLC22A1 Primary Antibody for EIA, FACS - ABIN1109041
Zach, Krieger, Foedermayr, Zellhofer, Lutz: OCT1 (SLC22A1) R61C polymorphism and response to imatinib treatment in chronic myeloid leukemia patients. in Leukemia & lymphoma 2008
Show all 3 references for ABIN1109041
Human Monoclonal SLC22A1 Primary Antibody for FACS, ELISA - ABIN969400
Hirayama, Watanabe, Nakashima, Nanbu, Hamada, Kuniyasu, Nakayama, Kawaguchi, Saito: Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells. in Pharmaceutical research 2008
Show all 3 references for ABIN969400
Human Polyclonal SLC22A1 Primary Antibody for IHC, WB - ABIN2776916
Bourdet, Pritchard, Thakker: Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). in The Journal of pharmacology and experimental therapeutics 2005
Show all 2 references for ABIN2776916
genetic association studies in population of patients newly diagnosed type 2 diabetes in Bosnia and Herzegovina: Data suggest that genetic variations in OCT1 (show POU2F1 Antibodies) [R61C (rs12208357); M420del (rs72552763)] are associated with severe intolerance/gastrointestinal side effects due to metformin use in patients with type 2 diabetes.
This study indicates a promising role for intratumoral OCT1 (show POU2F1 Antibodies) mRNA expression as a prognostic biomarker in therapeutic algorithms in HCC (show FAM126A Antibodies)
Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier (show SERTAD2 Antibodies) organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC (show PKC Antibodies))-independent manner.
Homozygous carriers of the polymorphic OCT1 (show POU2F1 Antibodies) C-allele had no metformin-related toxicity as compared with 41.9% for any metformin-related toxicity in carriers of at least one wild-type A-allele
A positive association was observed between the expression of the ABCB1 (show ABCB1 Antibodies) and ABCG2 (show ABCG2 Antibodies) transporter genes (r=0.407, P<0.05) while no association was observed between the expression of either of the ABC transporter (show ABCG2 Antibodies) genes with the OCT1 (show POU2F1 Antibodies) gene
Data indicate no association was found between genotypes of drug transporters ABCB1 (show ABCB1 Antibodies), ABCG2 (show ABCG2 Antibodies), OCT1 (show POU2F1 Antibodies) genetic polymorphisms and the occurrence of thrombocytopenia.
Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Antibodies)-3) in drug transportation.
Our data suggest that besides bodyweight, OCT1 (show POU2F1 Antibodies) and ABCC3 (show ABCC3 Antibodies) genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children
Nucleoside transporters and human OCT1 (show POU2F1 Antibodies) determine the cellular handling of DNA-methyltransferase (show DNMT1 Antibodies) inhibitors
The hOCT1 expression level can be an important predictor in CML patients treated with IM.
Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (show POU2F1 Antibodies) and OCT-2 (show SLC22A2 Antibodies).
Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 (show SLC22A2 Antibodies) and Slc22a3 (show OCT3 Antibodies) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Antibodies)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
The influence of organic cation transporters 1, 2, and 3 (OCT1 (show POU2F1 Antibodies), OCT2 (show SLC22A2 Antibodies), and OCT3 (show POU5F1 Antibodies)) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.
Oct1 (show POU2F1 Antibodies) forms repeating, cyclosporin-sensitive regulatory modules within the CD21 (show CR2 Antibodies) intronic control region.
a comparison of the transport properties of Oct2 (show SLC22A2 Antibodies) and Oct1 (show POU2F1 Antibodies)
oct1 (show POU2F1 Antibodies) has a role in controlling fgl2 (show FGL2 Antibodies) expression in endothelial cells
This study shows that Oct1 (show POU2F1 Antibodies) and Oct2 (show SLC22A2 Antibodies) together are essential for renal secretion of (small) organic cations.
nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene
The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1.
a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
solute carrier family 22 member 1
, solute carrier family 22 (organic cation transporter), member 1
, solute carrier family 22 member 1-like
, organic cation transporter 1
, solute carrier family 22, member 1
, solute carrier family 22 (organic cation transporter), member 2