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The protein encoded by SLC31A1 is a high-affinity copper transporter found in the cell membrane. Additionally we are shipping Solute Carrier Family 31 (Copper Transporters), Member 1 Kits (11) and Solute Carrier Family 31 (Copper Transporters), Member 1 Proteins (3) and many more products for this protein.
Showing 10 out of 78 products:
Human Polyclonal SLC31A1 Primary Antibody for ICC, IHC (fro) - ABIN151866
Holzer, Howell: The internalization and degradation of human copper transporter 1 following cisplatin exposure. in Cancer research 2006
Show all 12 references for ABIN151866
Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2 (show SLC31A2 Antibodies), COPT6, CSD1, CSD2 (show TGFB1 Antibodies), miRNA398 b/c precursors and FSD1 (show FSD1 Antibodies).
Col (show HDAC1 Antibodies)-0, high-affinity copper transporter COPT1-overexpressing (C1(OE)) seedlings and T-DNA COPT1 insertion mutant (copt1) differ in their copper-transport activity. C1(OE) showed a fivefold higher Cu-induced K(+) efflux at the root tip compared with Col (show HDAC1 Antibodies)-0.
CTR1 recycling via clathrin-mediated and Rab11 pathways enable cells to dynamically modulate copper entry
C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1 (show ATOX1 Antibodies)
Studied the interaction of CTR1 and CTR2 (show SLC31A2 Antibodies) in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system.
High CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer.
Gene silencing of either CTR1 or DMT1 (show DMRT1 Antibodies) did not affect copper accumulation in cells, but deficiency in both CTR1 and DMT1 (show DMRT1 Antibodies) resulted in a complete inhibition of copper uptake.
Two methionine residues in the MXXXM motif of of the CTR1 second transmembrane domain are important for binding to silver.
CTR1, ATP7A (show ATP7A Antibodies), and lysyl oxidase (show LOX Antibodies) were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
Data suggest that SLC31A1 and SLC31A2 (show SLC31A2 Antibodies), despite being structurally closely related and sharing important amino acid motifs, play different roles in copper homeostasis and in platinum-based chemotherapy of neoplasms. [REVIEW]
allele distribution of the SLC31A1 was not different between group N and O, and out of the 11 SNPs of the SLC22A2 (show SLC22A2 Antibodies) gene only the allele distribution of the nonsynonymous SNP was significantly different between patients who experienced ototoxicity
Extracellular copper concentrations regulate the levels of CTR1 through internalisation and degradation, the addition of prolactin (show PRL Antibodies), inhibits the degradation of CTR1, thus promoting copper uptake by mammary epithelial cells.
Studies show that zebrafish ctr1 is an essential gene for development.
studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition
conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4 (show IRS4 Antibodies)
A key regulatory mechanism for mammalian copper transport is through Ctr2 (show SLC31A2 Antibodies)-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto (show TRIM33 Antibodies)-domain.
conclude that Cu acquired from CTR1 is required for signaling in pathways regulated by RTKs that play major roles in development and cance
There was little difference in rates/kinetics of uptake of copper in the Ctr1+/+ and -/- cells. Endocytosis was not involved.
basal expression of Ctr1 is regulated by HIF2alpha (show EPAS1 Antibodies); however, the induction by hypoxia is a HIF2alpha (show EPAS1 Antibodies)-independent event
Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin
Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.
Ctr1 is an important transport protein in the accumulation of silver in mammalian cells.
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.
solute carrier family 31 (copper transporters), member 1
, high affinity copper uptake protein 1
, Copper transporter 1
, copper transporter 1
, solute carrier family 31 member 1
, copper transport 1 homolog
, Copper uptake transporter 1
, liver regeneration-related protein LRRGT00200
, high affinity copper uptake protein
, solute carrier family 13 (sodium/sulphate symporters), member 1