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Solute Carrier Family 34 (Sodium Phosphate), Member 2 Proteins (SLC34A2)

The protein encoded by SLC34A2 is a pH-sensitive sodium-dependent phosphate transporter. Additionally we are shipping SLC34A2 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC34A2 20531 Q9DBP0
SLC34A2 10568 O95436
Rat SLC34A2 SLC34A2 84395 Q9JJ09
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Top SLC34A2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details

SLC34A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
,

More Proteins for Solute Carrier Family 34 (Sodium Phosphate), Member 2 (SLC34A2) Interaction Partners

Pig (Porcine) Solute Carrier Family 34 (Sodium Phosphate), Member 2 (SLC34A2) interaction partners

  1. A sodium-dependent phosphate transporter gene, NaPi-IIb, was isolated from swine small intestine using cDNA library screening method.

Mouse (Murine) Solute Carrier Family 34 (Sodium Phosphate), Member 2 (SLC34A2) interaction partners

  1. This study validated the role of Npt2b in the pathogenesis of Pulmonary alveolar microlithiasis (PAM (show PAM Proteins)).

  2. Overall, our preclinical results suggest that the ADC (show ADC Proteins) targeting NaPi2b provides an effective new therapy for the treatment of NSCLC and ovarian cancer and is currently undergoing clinical developments.

  3. NaPi-IIb is the only luminal Na(+) -dependent Pi transporter in the murine ileum and its absence is fully compensated for in adult females by a mechanism involving the bone-kidney axis.

  4. Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis.

  5. B-RAF (show SNRPE Proteins) increases the cell surface protein (show CD28 Proteins) abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa (show SLC34A1 Proteins) and NaPi-IIb.

  6. that NHERF1 (show SLC9A3R2 Proteins) associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.

  7. Compared with wild-type uremic mice, Npt2b-deficient uremic mice had significantly lower levels of serum phosphate and attenuation of FGF23 (show FGF23 Proteins).

  8. Npt2b is an important target for the prevention of hyperphosphatemia

  9. In GABARAP (show GABARAP Proteins)-deficient mice renal NaPi-IIa (show SLC34A1 Proteins) is up-regulation and intestinal NaPi-IIb is downregulated.

  10. NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros (show ROS1 Proteins) transgenic mouse

Human Solute Carrier Family 34 (Sodium Phosphate), Member 2 (SLC34A2) interaction partners

  1. SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb

  2. our data indicated that SLC34A2 could exert significantly suppressive effects on tumorigenesis and progression of NSCLC. SLC34A2 might provide new insights for further understanding the early pathogenesis of human non-small cell lung cancer

  3. SLC34A2 might be associated with the initiation and progression of lung adenocarcinoma

  4. Data indicate that humanized monoclonal antibody Rebmab200 and murine monoclonal antibody MX35 monoclonal antibodies had similar specificity for sodium phosphate transporter NaPi2b.

  5. investigation revealed that the c.910A > T mutation in the SCL34A2 gene was responsible for pulmonary alveolar microlithiasis (PAM (show PAM Proteins)) patients in China

  6. identified 2 cases of pulmonary alveolar microlithiasis(PAM (show PAM Proteins)) with new mutations of SLC34A2 gene; identified the NaPi-IIb in a aortic valve; hypothesize that mutations in SLC34A2 may play a role in development of aortic valve calcification and arteriosclerosis

  7. The performed study revealed that SLC34A2 gene exhibited the most distinct change in expression and may become a molecular marker of papillary thyroid cancer

  8. Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.

  9. There was a significantly increased gene expression of SLC34A2 (normal tissues: 6.71+/-0.77; tumour tissues: 10.29+/-0.80) among breast cancer tissues compared with normal tissues.

  10. In human lung alveolar epithelial cells, the content of calcium and phosphate in cell supernatant decreased with increased amount of SLC34A2 mRNA.

SLC34A2 Protein Profile

Protein Summary

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with SLC34A2

  • solute carrier family 34 (sodium phosphate), member 2 (SLC34A2)
  • solute carrier family 34 (sodium phosphate), member 2 (Slc34a2)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 2 (SLC34A2)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 2 (Slc34a2)
  • AA536683 protein
  • D5Ertd227e protein
  • NaPi-2b protein
  • NAPI-3B protein
  • NAPI-IIb protein
  • Npt2b protein
  • NPTIIb protein
  • SLC34A2 protein

Protein level used designations for SLC34A2

Na/Pi cotransporter NaPi-IIb , sodium-dependent phosphate transport protein 2B , type IIb sodium phosphate cotransporter , solute carrier family 34 (sodium phosphate), member 2 , sodium-dependent phosphate cotransporter isoform NaPi-IIb , Na(+)-dependent phosphate cotransporter 2B , Na(+)/Pi cotransporter 2B , sodium-phosphate transport protein 2B , sodium/phosphate cotransporter 2B , solute carrier family 34 member 2 , type IIb Na/Picotransporter , naPi-2b , type II sodium-dependent phosphate transporter 3b , rNaPi IIb , type IIb sodium-phosphate transporter

GENE ID SPECIES
395131 Gallus gallus
471424 Pan troglodytes
488850 Canis lupus familiaris
641347 Sus scrofa
694217 Macaca mulatta
20531 Mus musculus
282484 Bos taurus
100171622 Pongo abelii
10568 Homo sapiens
84395 Rattus norvegicus
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