Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) Proteins (SLC4A2)

Plasma membrane anion exchange protein of wide distribution.. Additionally we are shipping SLC4A2 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC4A2 6522 P04920
SLC4A2 20535 P13808
Rat SLC4A2 SLC4A2 24780 P23347
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Top SLC4A2 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

SLC4A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) Interaction Partners

Human Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. ABA transport in human nucleated cells occurs via the anion exchanger AE2

  2. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase (show ADCY10 Proteins)

  3. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu (show CALU Proteins)-3 cells

  4. A novel signal pathway involved in gastrin (show GAST Proteins)-stimulated AE2 expression mediated by EGR1 (show EGR1 Proteins) in gastric cancer cells.

  5. miR (show MLXIP Proteins)-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions.

  6. CTLA4 (show CTLA4 Proteins) and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 (show NUP210 Proteins) or anti-centromere antibody production, in Japanese PBC (show DLAT Proteins) patients

  7. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis.

  8. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3 (show CASP3 Proteins)-dependent.

  9. AE2 operates in parallel with NHE1 (show SLC9A1 Proteins) to regulate pH(i) during RVD of human cervical cancer cells.

  10. Oxidative stress activates anion exchange protein 2 and AP-1 (show FOSB Proteins) in airway epithelial cells.

Cow (Bovine) Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. These results indicate that a deletion mutation within bovine SLC4A2 is associated with osteopetrosis (show CSF1 Proteins) in Red Angus cattle.

Mouse (Murine) Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 (show CLEC7A Proteins) expression and fungal clearance is regulated.

  2. Data indicate a key functional role of anion exchanger 2 (AE2) in the maintenance of the normal physiology of biliary epithelial cells (BEC) and the pathogenic consequences of reduced AE2 expression, including abnormal intrinsic characteristics of BEC and their production of signal molecules that lead to the chronic inflammatory responses in small bile ducts.

  3. AE2 deficiency results in intrahepatic T-cell activation and PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) mediated deletion, favoring autoimmune cholangitis.

  4. GnRH (show GNRH1 Proteins) neurons were immunopositive for NKCC1 (show SLC12A2 Proteins) and AE2.

  5. These findings demonstrate that CD8 (show CD8A Proteins)(+) T cells are critically dependent on Ae2 for pHi homeostasis and tuning of cell proliferation and activation. Ae2 thus constitutes a novel target to modulate CD8 (show CD8A Proteins)(+) T-cell responses.

  6. Rescue of SLC4A2-deficient osteoclasts with functionally defined mutants of SLC4A2 indicates regulation of actin cytoskeletal reorganization by anion-exchange activity and intracellular pH, independent of SLC4A2's long N-terminal cytoplasmic domain.

  7. expression of Slc4a2 significantly decreased in enamel organs from Mmp20 (show MMP20 Proteins)(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.

  8. AE2 is a component of the basolateral ion transport mechanisms that support anion secretion in the proximal colon.

  9. GFP-tagged Ae2 localization depends upon MAPK (show MAPK1 Proteins) activity

  10. results are consistent with the hypothesis that AE2 mediates the major portion of the exchange across the basolateral membrane of mouse parotid and sublingual acinar cells

SLC4A2 Protein Profile

Protein Summary

This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes.

Gene names and symbols associated with SLC4A2

  • solute carrier family 4 (anion exchanger), member 2 (SLC4A2)
  • solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) (SLC4A2)
  • solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) (LOC100224615)
  • neuroblastoma breakpoint family, member 3 (NBPF3)
  • solute carrier family 4 (anion exchanger), member 2 (Slc4a2)
  • Ae2 protein
  • Aep2 protein
  • B3RP protein
  • BND3L protein
  • EPB3L1 protein
  • HKB3 protein
  • NBND3 protein
  • SLC4A2 protein

Protein level used designations for SLC4A2

AE 2 , anion exchange protein 2 , anion exchanger 2 type a , anion exchanger 2 type b1 , anion exchanger 2 type b2 , erythrocyte membrane protein band 3-like 1 , non-erythroid band 3-like protein , solute carrier family 4 member 2 , AE2-1 anion exchanger , chloride-bicarbonate anion exchanger AE2 , SLC4A2 anion exchanger , chloride-bicarbonate exchanger , solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) , anion exchanger 2 , band 3-related protein , neuroblastoma breakpoint family member 3 , protein SHIIIa4 , B3RP-2 , Solute carrier family 4, member 2, anion exchange protein 2 , band 3-related protein 2 , AE2 anion exchanger , anion exchanger 2 a

GENE ID SPECIES
6522 Homo sapiens
395809 Gallus gallus
397203 Sus scrofa
404084 Bos taurus
463890 Pan troglodytes
475538 Canis lupus familiaris
713966 Macaca mulatta
100009159 Oryctolagus cuniculus
100172030 Pongo abelii
100224615 Taeniopygia guttata
100599599 Nomascus leucogenys
84224 Homo sapiens
20535 Mus musculus
24780 Rattus norvegicus
100135618 Cavia porcellus
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