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The protein encoded by Slc7a7 is the light subunit of a cationic amino acid transporter. Additionally we are shipping Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Antibodies (12) and Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Proteins (4) and many more products for this protein.
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heteromerization of y+LAT1 and 4F2hc (show SLC3A2 ELISA Kits) within the cell is not disrupted by any of the tested LPI mutations
SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population.
SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients
SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance.
during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased
novel SLC7A7 mutations in patients with lysinuric protein intolerance
expression levels and putative 5' promoter elements of the SLC7A7 gene
putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance
mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance
identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression
The expression of Mct8 (show MCT8 ELISA Kits) and L-type amino acid transporters Lat2 (show SLC7A8 ELISA Kits) and Lat1 (show SLC7A5 ELISA Kits) are determined in brain neurons during development.
Increased LAT1 (show SLC7A5 ELISA Kits) expression can be induced by lipid oxidation products relevant to inflammatory responses in atherogenesis. LAT1 (show SLC7A5 ELISA Kits) mediates lysophosphatidylcholine-enhanced cytokine production by endothelial cells.
selective regulation of SNAT3 (show SLC38A3 ELISA Kits) and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance.
The Slc7a7(-/-) mouse displayed intrauterine growth restriction, leading to neonatal lethality. After heavy protein ingestion, the surviving adult animals presented metabolic derangement consistent with lysinuric protein intolerance.
LAT1 (show SLC7A5 ELISA Kits), and LAT2 (show SLC7A8 ELISA Kits) mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 (show Slco1a1 ELISA Kits) and NTCP (show SLC10A1 ELISA Kits) mRNAs were not.
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants.
Y+L amino acid transporter 1
, monocyte amino acid permease 2
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
, y(+)L-type amino acid transporter 1
, solute carrier family 7 member 7