You are viewing an incomplete version of our website. Please click to reload the website as full version.

Sprouty Homolog 4 (Drosophila) Proteins (SPRY4)

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Additionally we are shipping SPRY4 Antibodies (75) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SPRY4 SPRY4 291610  
SPRY4 81848 Q9C004
SPRY4 24066 Q9WTP2
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top SPRY4 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days

SPRY4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Sprouty Homolog 4 (Drosophila) (SPRY4) Interaction Partners

Human Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (show MMP14 Proteins) affecting melanoma cell motility.

  2. Data show that proto-oncogene (show RAB1A Proteins) protein B (show LEPREL2 Proteins)-raf (BRAF (show BRAF Proteins)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN Proteins) abundance and activation by down-regulating SPRY2 (show SPRY2 Proteins)/4 protein expression.

  3. Specific protein 1 (show SP1 Proteins) plays a crucial role in the regulation of Sprouty4 in response to serum.

  4. ZNF703 (show ZNF703 Proteins) was a target of SPRY4-IT1 (show HAUS3 Proteins).

  5. SPRY4 is often deleted in secondary acute myeloid leukemia (show BCL11A Proteins).

  6. Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.

  7. these results suggest the possibility that SPRY4-IT1 (show HAUS3 Proteins) knockdown may induce apoptosis via lipin 2 (show LPIN2 Proteins)-mediated alterations in lipid metabolism leading to cellular lipotoxicity.

  8. SPRY4 may function as a tumor suppressor in endometrial adenocarcinoma.

  9. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.

  10. demonstrated that knockdown of SPRY4-IT1 (show HAUS3 Proteins) reduced cell proliferation, invasiveness, and migration

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Autoregulatory loop between TGF-beta1 (show TGFB1 Proteins)/miR (show MLXIP Proteins)-411-5p/SPRY4 and p38 MAPK (show MAPK14 Proteins) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

  2. in embryos with lower Spry2 (show SPRY2 Proteins);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Proteins) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  3. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (show TNF Proteins) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

  4. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (show BCL11A Proteins) subtype.

  5. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs.

  6. We propose that Sprouty genes(Spry2 (show SPRY2 Proteins) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

  7. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.

  8. our results imply that Sprouty2 (show SPRY2 Proteins) and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.

  9. Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.

  10. Spry4 and Tpbg/5T4 (show TPBG Proteins) were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.

SPRY4 Protein Profile

Protein Summary

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Gene names and symbols associated with SPRY4

  • sprouty homolog 4 (Drosophila) (Spry4)
  • sprouty homolog 4 (Drosophila) (SPRY4)
  • sprouty homolog 4 (SPRY4)
  • sprouty (Drosophila) homolog 4 (spry4)
  • sprouty homolog 4 (LOC100218545)
  • A030006O18Rik protein
  • HH17 protein
  • LOC100218545 protein
  • sprouty4 protein
  • SPRY4 protein

Protein level used designations for SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
Selected quality suppliers for SPRY4 Proteins (SPRY4)
Did you look for something else?