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Stearoyl-CoA Desaturase (Delta-9-Desaturase) Proteins (SCD)

SCD encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Additionally we are shipping Stearoyl-CoA Desaturase (Delta-9-Desaturase) Antibodies (70) and Stearoyl-CoA Desaturase (Delta-9-Desaturase) Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCD 6319 O00767
Rat SCD SCD 83792 Q6P7B9
SCD 20249 P13516
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Top Stearoyl-CoA Desaturase (Delta-9-Desaturase) Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days

SCD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) Interaction Partners

Zebrafish Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. whole-mount in situ hybridization and real-time quantitative RT-PCR to identify expression of the zebrafish SCD gene at five different stages of development

Human Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. Chronic exposure to chewing tobacco induces carcinogenesis in non-malignant oral epithelial cells and SCD plays an essential role in this process.

  2. This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.

  3. The data indicate a direct inhibitory interaction of polyunsaturated fatty acids with LXRalpha (show NR1H3 Proteins), a consequent reduction of SREBP-1 (show SREBF1 Proteins) and of its binding to SCD1 promoter.

  4. Both siRNA-mediated and pharmacological inhibition of SCD1 impaired tumor cells migration.

  5. SCD1 is found upregulated upon renal cell transformation indicating that its activity, while not impacting proliferation, represents a critical bottleneck for tumourigenesis

  6. SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK (show PRKAA1 Proteins) signaling pathway.

  7. An association with Graves ophthalmopathy was shown for SNP rs1393491 in SCD.

  8. Stearoyl-CoA desaturase is encoded by an SCD gene, which, depending on the species, may exist as different isoforms. (review)

  9. DNA methylation (show HELLS Proteins) levels of the SCD1 promoter were associated with weight change and with adherence to a Mediterranean diet.

  10. These data further support the idea that SCD1 is associated with hepatitis C virus replication complex and that its products may contribute to the proper formation and maintenance of membranous web structures during virus replication.

Cow (Bovine) Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. Studied the responsiveness of bovine SCD1 promoter to serum, insulin (show INS Proteins), oleic acid, and NFY transcription factor in BME-UV1 cells.

  2. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  3. Suppression of CPT1B (show CPT1B Proteins) and induction of SCD and CEBPB (show CEBPB Proteins) by supplemental arginine promotes increased adiposity in Angus steers.

  4. This study showed that milk somatic cells can be used as a source of mRNA to study SCD1 expression in dairy cows, offering a non-invasive alternative to mammary tissue samples obtained by biopsy.

  5. This study presents evidence that there are breed- and diet-induced variations on lipid metabolism in the muscle, which may be, at least partially, modulated by the stearoyl-CoA desaturase (SCD) gene expression levels.

  6. These results provide detailed genetic information for the SREBP1 (show SREBF1 Proteins) signalling pathway and SCD that can be used to change milk fat composition by marker-assisted breeding.

  7. study evaluated the contributions of polymorphisms of FASN (show FASN Proteins) and SCD genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations

  8. Results suggest that SCD and FASN (show FASN Proteins) are strong candidate genes influencing fatty acid composition in beef cattle.

  9. The expression of the stearoyl-CoA desaturase gene was higher in the adipose tissue of heifers compared to bulls and gene expression is partly associated with adipose tissue fatty acid composition.

  10. The effects of genetic polymorphisms of liver X receptor, alpha (LXR (show NR1H3 Proteins)), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

Pig (Porcine) Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. genetic association study in Duroc gilts/barrows in Spain: Data suggest that T allele in promoter region of SCD (2228T>C) leads to up-regulation of monounsaturated fatty acid content of biceps femoris/ham which is maintained in dry-cured ham.

  2. The study provides evidence that there exists genetic variation in the SCD gene with the potential to increase monounsaturated content in pork.

  3. There was a positive relationship between stearoyl-CoA desaturase (SCD) protein expression in longissimus muscle and monounsaturated fatty acid content, and SCD protein expression and total muscle fatty acid content in Large White x Landrace breeds.

  4. The relationships between a point mutation of SCD and multiple production traits in swine are reported.

  5. The results indicate that the haplotype of the SCD gene has a strong effect on fatty acid composition and melting point of fat.

  6. Stearoyl-CoA desaturase(SCD) has a total of 21 gene polymorphisms in the 21-kb DNA sequence, adn (show CFD Proteins) RT-PCR result indicates that the SCD gene is expressed ubiquitously in tissues.

Mouse (Murine) Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. Scd1 Is Regulated by Dbc1 (show DBC1 Proteins) and SirT1 (show SIRT1 Proteins).

  2. Study provides new insights into the critical role of SCD1 as a regulator of adipocyte function and lipid metabolism.

  3. The study reports report the 3.25-A crystal structure of human SCD1 in complex with its substrate, stearoyl-coenzyme A, which defines the new SCD1 dimetal catalytic center and reveals the determinants of substrate binding.

  4. SCD1 is a novel oncogenic factor specifically required for tumor cell viability in anaplastic thyroid carcinoma.

  5. crystal structure of mouse SCD1 bound to stearoyl-CoA at 2.6 A resolution

  6. Data indicate that lowering stearoyl-CoA desaturase-1 (SCD-1) activity specifically activates p38 mitogen-activated protein kinase (show MAPK14 Proteins) (P38MAPK (show MAPK14 Proteins)).

  7. Results provide new mechanistic insight into the role of SCD1 as a regulator of fatty acid profiles and Triacylglycerol (TG) synthesis in adipocytes, and reinforce that modulating SCD1 activity may help reduce the risk of obesity-related complications.

  8. Data indicate that global DNA methylation (show HELLS Proteins) level in adipocytes depends on stearoyl-CoA desaturase 1 (SCD1) expression/activity.

  9. Results show that SCD1 was expressed selectively in the S3 segment of proximal tubule cells, and SCD1 abundance was increased in uromodulin (show UMOD Proteins)-associated kidney disease affected kidneys.

  10. Data indicate that hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in cytochrome P450 1B1 (CYP1B1 (show CYP1B1 Proteins))-null mice.

Arabidopsis thaliana Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) interaction partners

  1. SCD1 and SCD2 function in clathrin-mediated membrane trafficking essential to both cytokinesis and cell expansion.

Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD) Protein Profile

Protein Summary

This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.

Gene names and symbols associated with SCD

  • stearoyl-CoA desaturase (delta-9-desaturase) (scd)
  • stearoyl-CoA desaturase (delta-9-desaturase) (SCD)
  • acyl-CoA delta-11 desaturase/conjugase (Desat1)
  • acyl-CoA desaturase (Desat3)
  • stearoyl-CoA desaturase (SCD)
  • acyl-CoA desaturase (CIMG_08158)
  • acyl-CoA desaturase (VIBHAR_06094)
  • Acyl-CoA desaturase (acod)
  • stearoyl-CoA desaturase 1 (LOC100346561)
  • stearoyl-CoA desaturase (delta-9-desaturase) (Scd)
  • stearoyl-Coenzyme A desaturase 1 (Scd1)
  • stomatal cytokinesis defective / SCD1 protein (SCD1) (SCD1)
  • AA589638 protein
  • ab protein
  • ACD protein
  • AI265570 protein
  • Desat2 protein
  • F27J15.17 protein
  • F27J15_17 protein
  • FADS5 protein
  • MSTP008 protein
  • Scd protein
  • Scd-1 protein
  • SCD1 protein
  • Scd2 protein
  • SCDOS protein

Protein level used designations for SCD

SCD1 , stearoyl-CoA desaturase 5 , stearoyl-CoA desaturase 1 , delta-9 desaturase , acyl-CoA delta-11 desaturase/conjugase , acyl CoA desaturase , pheromone gland-specific acyl-CoA desaturase , acyl-CoA desaturase , stearoyl-CoA desaturase , delta-9-desaturase , Acyl-CoA desaturase , stearoyl-CoA desaturase (delta-9-desaturase) , delta(9)-desaturase , fatty acid desaturase , predicted protein of HQ0998 , stearoyl-CoA desaturase opposite strand , stearoyl-coenzyme A desaturase , acyl-CoA desaturase 2 , delta(9)-desaturase 2 , delta-9 desaturase 2 , fatty acid desaturase 2 , stearoyl-CoA desaturase 2 , stearoyl-Coenzyme A desaturase 2 , acyl-CoA desaturase 1 , asebia , delta(9)-desaturase 1 , delta-9 desaturase 1 , fatty acid desaturase 1

386661 Danio rerio
395706 Gallus gallus
692567 Bombyx mori
692568 Bombyx mori
710155 Macaca mulatta
4560468 Coccidioides immitis RS
5556852 Vibrio campbellii ATCC BAA-1116
100126751 Papio anubis
100172656 Pongo abelii
100194951 Salmo salar
100346561 Oryctolagus cuniculus
447633 Xenopus laevis
450676 Pan troglodytes
486839 Canis lupus familiaris
613092 Xenopus (Silurana) tropicalis
6319 Homo sapiens
280924 Bos taurus
396670 Sus scrofa
443185 Ovis aries
83792 Rattus norvegicus
20249 Mus musculus
246074 Rattus norvegicus
841327 Arabidopsis thaliana
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