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Steroid 5 alpha-Reductase 3 Proteins (SRD5A3)

The protein encoded by SRD5A3 belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. Additionally we are shipping Steroid 5 alpha-Reductase 3 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRD5A3 79644 Q9H8P0
SRD5A3 57357 Q9WUP4
Rat SRD5A3 SRD5A3 305291 Q5RJM1
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Top Steroid 5 alpha-Reductase 3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SRD5A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Steroid 5 alpha-Reductase 3 (SRD5A3) Interaction Partners

Human Steroid 5 alpha-Reductase 3 (SRD5A3) interaction partners

  1. the spectrum of phenotypes resulting from SRD5A3 mutations and the clinical variability of SRD5A3-CDG

  2. Findings suggest that overexpression of 5alpha-reductase, through a higher inactivation of cortisol in the liver, could have a protective role in preserving hepatic sensitivity to insulin (show INS Proteins).

  3. Next generation sequencing identified a homozygous frameshift mutation (c.203dupC; p.Phe69LeufsX2) SRD5A3 as the disease-causing change in Kahrizi syndrome.

  4. A novel syndrome is identified in families with cerebellar ataxia (show USP14 Proteins) and congenital eye malformations due to steroid 5 alpha-reductase type 3 disorders of glycosylation.

  5. Study of a large consanguineous Emirati family showed that loss of function mutations of the SRD5A3 gene cause a multisystemic syndrome with eye malformations, cerebellar vermis hypoplasia, and psychomotor delay.

  6. Findings indicate that a novel type 3 5 alpha-steroid reductase, SRD5A3, is associated with DHT production and maintenance of androgen-androgen receptor (show AR Proteins)-pathway activation in prostate cancer.

Mouse (Murine) Steroid 5 alpha-Reductase 3 (SRD5A3) interaction partners

  1. Srd5a3 mutation is lethal in mouse and results in an activation of the unfolded protein response pathway.

Steroid 5 alpha-Reductase 3 (SRD5A3) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq.

Gene names and symbols associated with SRD5A3

  • steroid 5 alpha-reductase 3 (SRD5A3)
  • steroid 5 alpha-reductase 3 (Srd5a3)
  • steroid 5 alpha-reductase 3 (srd5a3)
  • 1110025P14Rik protein
  • A430076C09 protein
  • AV364670 protein
  • AW987574 protein
  • CDG1P protein
  • CDG1Q protein
  • D730040M03Rik protein
  • H5ar protein
  • KRIZI protein
  • RGD1308828 protein
  • S5AR 3 protein
  • Srd5a2l protein
  • SRD5A2L1 protein
  • SRD5alpha3 protein

Protein level used designations for SRD5A3

3-oxo-5-alpha-steroid 4-dehydrogenase 3 , S5AR 3 , SR type 3 , polyprenol reductase , probable polyprenol reductase , H5AR , steroid 5 alpha-reductase 2 like , steroid 5 alpha-reductase 2-like; H5AR gene; steroid 5 alpha-reductase 2 like , steroid 5-alpha-reductase 3 , Probable polyprenol reductase , Steroid 5-alpha-reductase 3

GENE ID SPECIES
79644 Homo sapiens
482155 Canis lupus familiaris
535834 Bos taurus
57357 Mus musculus
305291 Rattus norvegicus
379123 Xenopus laevis
100463734 Ailuropoda melanoleuca
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