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anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Antibodies

SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. Additionally we are shipping Sterol Regulatory Element Binding Transcription Factor 2 Proteins (10) and Sterol Regulatory Element Binding Transcription Factor 2 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SREBF2 20788 Q3U1N2
SREBF2 6721 Q12772
SREBF2 300095 Q3T1I5
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Top anti-Sterol Regulatory Element Binding Transcription Factor 2 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of SREBF2 Antibody (Center) (ABIN654630) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SREBF2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Raji cell lysate WB Suggested Anti-SREBF2 Antibody  Positive Control: Lane 1:541 µg mouse glomerular endothelial lysate Primary Antibody Dilution: 1:0000Secondary Antibody: Anti-rabbit-HRP Secondry  Antibody Dilution: 1:0000Submitted by: Xiaoxin Wang, UC Denver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Confocal immunofluorescent analysis with HepG2 cells using SREBF2 / SREBP2  Antibody , followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Immunohistochemistry analysis in human skin carcinoma, followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SREBF2 antibody for IHC; Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IP, WB Western blot analysis of SREBP-2. Jurkat (ATCC TIB-152) cells were left untreated (lanes 1 & 2) or treated with 1 µM Staurosporin for 4 hours (lanes 3 & 4) to induce apoptosis. Cell lysates were probed with Purified Mouse Anti-SREBP-2 (ABIN967564). As apoptosis is induced, the SREBP-2 125 kDa precursor is cleaved to its ~70 kDa size. 0.1 mg Log in to see 5 to 6 Days
$236.41
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SREBF2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:7812500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using SREBF2, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ChIP, WB   100 μg Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated WB SREBF2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the SREBP2 antibody detected the SREBP2 protein (arrow). SREBP2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SREBP2 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 100 μL Log in to see 2 to 3 Days
$304.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

SREBF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,



Human ,
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Rat (Rattus) , ,



Top referenced anti-Sterol Regulatory Element Binding Transcription Factor 2 Antibodies

  1. Human Polyclonal SREBF2 Primary Antibody for EIA, IF - ABIN954950 : Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN954950

  2. Human Monoclonal SREBF2 Primary Antibody for IP, WB - ABIN967564 : Hua, Sakai, Ho, Goldstein, Brown: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. in The Journal of biological chemistry 1996 (PubMed)
    Show all 4 references for ABIN967564

  3. Human Polyclonal SREBF2 Primary Antibody for IF, IHC (p) - ABIN654630 : Marquart, Allen, Ory, Baldán: miR-33 links SREBP-2 induction to repression of sterol transporters. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for ABIN654630

  4. Human Monoclonal SREBF2 Primary Antibody for ChIP, WB - ABIN2668815 : Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. in PLoS ONE 2014 (PubMed)

  5. Chicken Polyclonal SREBF2 Primary Antibody for WB - ABIN2792226 : Zeng, Liao, Liu, Lee, Zhu, Wang, Stemerman, Zhu, Shyy: Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Sterol Regulatory Element Binding Transcription Factor 2 Interaction Partners

Mouse (Murine) Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) interaction partners

  1. This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).

  2. activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique

  3. ITCH modulates SIRT6 (show SIRT6 Antibodies) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (show APOE Antibodies) null mice

  4. SREBP2-induced miR-92a targets k (show MLXIP Antibodies)ey molecules in endothelial homeostasis, including sirtuin 1, Kruppel-like factor 2, and Kruppel-like factor 4, leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase inhibition.

  5. The cholesterol-lowering effects of FGF21 (show FGF21 Antibodies) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.

  6. Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.

  7. Demonstrate that the activation of FXR (show NR1H4 Antibodies) uncouples the expression of nuclear SREBP-2 and miR (show MLXIP Antibodies)-33, and the regulation of their respective target genes.

  8. the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase (show HMGCR Antibodies) pathway being upregulated in MMP-2 (show MMP2 Antibodies) deficiency.

  9. activation of intestinal SREBP2 alone seems to be sufficient to increase plasma cholesterol

  10. Hepatic insulin receptor (show INSR Antibodies) knockout mice manifest decreased nuclear SREBP-2 protein, decreased cholesterologenic gene expression, and decreased cholesterol synthesis.

Human Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) interaction partners

  1. Data show that mutant p53 protein (show TP53 Antibodies) activates the sterol regulatory element-binding proteins SREBP-1 (show SREBF1 Antibodies) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (show FLVCR1 Antibodies)) cells.

  2. The connections of EGFR (show EGFR Antibodies) and ERBB4 (show ERBB4 Antibodies) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (show EGFR Antibodies)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (show EGFR Antibodies)-driven cancers.

  3. Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) activated both SREBP-1 (show SREBF1 Antibodies) and SREBP-2, whereas Akt3 (show AKT3 Antibodies) upregulated SREBP-1 (show SREBF1 Antibodies) to enhance hepatitis C virus translation.

  4. knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (show Acsl1 Antibodies) mRNA and protein levels.

  5. Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (show NLRP3 Antibodies) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (show SREBF1 Antibodies)/SREBF2/SCAP (show SH2D2A Antibodies) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (show MBTPS1 Antibodies)/S2P (show MBTPS2 Antibodies).

  6. Data suggest lysophosphatidylcholine (LPC (show PCSK7 Antibodies)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (show PCSK7 Antibodies); both LPC (show PCSK7 Antibodies) and 25-HC up-regulate release of interleukin-6 (show IL6 Antibodies) and interleukin-8 (show IL8 Antibodies).

  7. the results of the present study showed that luteolin modulates HMGCR (show HMGCR Antibodies) transcription by decreasing the expression and nuclear translocation of SREBP-2.

  8. performed a detailed promoter/enhancer analysis of ELOVL5 (show ELOVL5 Antibodies) gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1

  9. HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein.

  10. the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR (show ATIC Antibodies))-induced activation of AMPK (show PRKAA1 Antibodies) directly inhibited the expression of SREBP-2 and HMGCR (show HMGCR Antibodies) and HMGCS (show HMGCS1 Antibodies), and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells.

Pig (Porcine) Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) interaction partners

  1. dysregulation of SIRT1 (show SIRT1 Antibodies)-AMPK (show PRKAA1 Antibodies)-SREBP and stimulation of NLRP3 (show NLRP3 Antibodies) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis

  2. KLF13 (show KLF13 Antibodies) and SREBP-Sp1 (show SP1 Antibodies) activation interact to regulate low density lipoprotein receptor (show LDLR Antibodies) promoter function

Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Antigen Profile

Protein Summary

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Gene names and symbols associated with SREBF2

  • sterol regulatory element binding transcription factor 2 (SREBF2) antibody
  • sterol regulatory element binding transcription factor 2 (srebf2) antibody
  • sterol regulatory element binding protein 2 (SREBP2) antibody
  • sterol regulatory element binding factor 2 (Srebf2) antibody
  • sterol regulatory element binding protein-2 (SREBP-2) antibody
  • sterol regulatory element binding transcription factor 2 (Srebf2) antibody
  • AI608257 antibody
  • bHLHd2 antibody
  • lop13 antibody
  • nuc antibody
  • SREBF2 antibody
  • Srebf2_retired antibody
  • SREBP-2 antibody
  • SREBP2 antibody
  • SREBP2gc antibody
  • zgc:158371 antibody

Protein level used designations for SREBF2

sterol regulatory element binding transcription factor 2 , sterol regulatory element-binding protein 2-like , sterol regulatory element binding protein 2 , SREBP-2 , sterol regulatory element-binding protein 2 , sterol regulatory element-binding transcription factor 2 , class D basic helix-loop-helix protein 2 , sterol regulatory element binding factor 2

GENE ID SPECIES
712307 Macaca mulatta
100070704 Equus caballus
100144677 Xenopus (Silurana) tropicalis
100480211 Ailuropoda melanoleuca
100552463 Anolis carolinensis
100124292 Monodelphis domestica
507102 Bos taurus
100037309 Danio rerio
100502557 Salmo salar
20788 Mus musculus
100008783 Oryctolagus cuniculus
443980 Xenopus laevis
395304 Gallus gallus
6721 Homo sapiens
481228 Canis lupus familiaris
396675 Sus scrofa
300095 Rattus norvegicus
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