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SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. Additionally we are shipping Sterol Regulatory Element Binding Transcription Factor 2 Proteins (10) and Sterol Regulatory Element Binding Transcription Factor 2 Kits (6) and many more products for this protein.
Showing 10 out of 88 products:
Chicken Monoclonal SREBF2 Primary Antibody for ELISA, GS - ABIN4355936
Janowski, Shan, Russell: The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. in The Journal of biological chemistry 2001
Show all 14 references for ABIN4355936
Human Polyclonal SREBF2 Primary Antibody for ICC, IF - ABIN261631
Huster, Purnat, Burkhead, Ralle, Fiehn, Stuckert, Olson, Teupser, Lutsenko: High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. in The Journal of biological chemistry 2007
Show all 6 references for ABIN261631
Human Polyclonal SREBF2 Primary Antibody for EIA, IF - ABIN954950
Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. in The Journal of biological chemistry 2010
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Human Monoclonal SREBF2 Primary Antibody for IP, WB - ABIN967564
Hua, Sakai, Ho, Goldstein, Brown: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. in The Journal of biological chemistry 1996
Show all 4 references for ABIN967564
Human Polyclonal SREBF2 Primary Antibody for IF, IHC (p) - ABIN654630
Marquart, Allen, Ory, Baldán: miR-33 links SREBP-2 induction to repression of sterol transporters. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 references for ABIN654630
Human Monoclonal SREBF2 Primary Antibody for ChIP, WB - ABIN2668815
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. in PLoS ONE 2014
Chicken Polyclonal SREBF2 Primary Antibody for WB - ABIN2792226
Zeng, Liao, Liu, Lee, Zhu, Wang, Stemerman, Zhu, Shyy: Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. in The Journal of biological chemistry 2004
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (show NGFR Antibodies) that via p38 MAPK (show MAPK14 Antibodies) and caspase-3 (show CASP3 Antibodies) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (show NGFB Antibodies) and pro-NGF (show NGFB Antibodies).
This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (show SIRT6 Antibodies) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (show APOE Antibodies) null mice
SREBP2-induced miR (show MLXIP Antibodies)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (show SIRT1 Antibodies), Kruppel-like factor 2, and Kruppel-like factor 4 (show KLF4 Antibodies), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (show NOS3 Antibodies) inhibition.
The cholesterol-lowering effects of FGF21 (show FGF21 Antibodies) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.
Demonstrate that the activation of FXR (show NR1H4 Antibodies) uncouples the expression of nuclear SREBP-2 and miR (show MLXIP Antibodies)-33, and the regulation of their respective target genes.
the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase (show HMGCR Antibodies) pathway being upregulated in MMP-2 (show MMP2 Antibodies) deficiency.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
Data show that mutant p53 protein (show TP53 Antibodies) activates the sterol regulatory element-binding proteins SREBP-1 (show SREBF1 Antibodies) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (show FLVCR1 Antibodies)) cells.
The connections of EGFR (show EGFR Antibodies) and ERBB4 (show ERBB4 Antibodies) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (show EGFR Antibodies)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (show EGFR Antibodies)-driven cancers.
Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) activated both SREBP-1 (show SREBF1 Antibodies) and SREBP-2, whereas Akt3 (show AKT3 Antibodies) upregulated SREBP-1 (show SREBF1 Antibodies) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (show Acsl1 Antibodies) mRNA and protein levels.
Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (show NLRP3 Antibodies) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (show SREBF1 Antibodies)/SREBF2/SCAP (show SH2D2A Antibodies) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (show MBTPS1 Antibodies)/S2P (show MBTPS2 Antibodies).
Data suggest lysophosphatidylcholine (LPC (show PCSK7 Antibodies)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (show PCSK7 Antibodies); both LPC (show PCSK7 Antibodies) and 25-HC up-regulate release of interleukin-6 (show IL6 Antibodies) and interleukin-8 (show IL8 Antibodies).
the results of the present study showed that luteolin modulates HMGCR (show HMGCR Antibodies) transcription by decreasing the expression and nuclear translocation of SREBP-2.
performed a detailed promoter/enhancer analysis of ELOVL5 (show ELOVL5 Antibodies) gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
dysregulation of SIRT1 (show SIRT1 Antibodies)-AMPK (show PRKAA1 Antibodies)-SREBP and stimulation of NLRP3 (show NLRP3 Antibodies) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (show KLF13 Antibodies) and SREBP-Sp1 (show SP1 Antibodies) activation interact to regulate low density lipoprotein receptor (show LDLR Antibodies) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2