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Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping SMC5 Antibodies (56) and many more products for this protein.
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The SMC5/6 complex promotes sister chromatid cohesion after DNA breakage and facilitates homologous recombination between sister chromatids.
The SMC5/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A (show TOP2A Proteins)).
results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression
Structural maintenance of chromosomes (SMC (show DYM Proteins)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics
Depletion of Smc5 and Smc6 (show SMC6 Proteins) resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors
Studies indicate that Nse1 (show FAM84A Proteins) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.
the human SMC5/6 complex and the SUMO ligase activity of hMMS21 (show NSMCE2 Proteins) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells
SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.
SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.
The four non-SMC components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 protein is part of this complex.
Nse1 (show FAM84A Proteins) RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 (show SMC6 Proteins) holocomplex integrity and recruitment to, or retention at, DNA lesions
The Smc5/6 complex is regulated during the cell cycle, presumably in anticipation of DNA damage that may arise during replication.
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression\; the function seems to be independent of SMC6 (By similarity).
SMC protein 5
, structural maintenance of chromosomes protein 5
, SMC5 structural maintenance of chromosomes 5-like 1
, protein expressed in male leptotene and zygotene spermatocytes 453