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Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa Proteins (SDHC)

SDHC encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. Additionally we are shipping SDHC Antibodies (44) and SDHC Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHC 66052 Q9CZB0
Rat SDHC SDHC 289217  
SDHC 6391 Q99643
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Top SDHC Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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SDHC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa (SDHC) Interaction Partners

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa (SDHC) interaction partners

  1. Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.

Human Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa (SDHC) interaction partners

  1. Loss of the SDHC gene is associated with metastatic sympathetic paraganglioma.

  2. This report provides evidence that SDHC promoter methylation can cause Paragangliomas due to SDHC inactivation

  3. significant association with overall survival were confirmed for SDHC gene, SDHD (show SDHD Proteins) gene and FH gene ... SDHC gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  4. This study strengthens the etiological association of SDH genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. Also, pancreatic neuroendocrine tumor falls within the SDH-related tumor spectrum.

  5. The discovery of SDHC epimutation provides a unifying explanation for the pathogenesis of SDH-deficient gastrointestinal stromal tumors.

  6. Variant in rs3935401 in the 3' untranslated region of SDHC is associated with hepatocellular carcinoma.

  7. these data suggest epigenetic inactivation of the SDHC gene locus with functional impairment of the SDHC as a plausible alternate mechanism of tumorigenesis in Carney Triad

  8. Overall, 9 of the 34 patients with KIT/PDGFRA (show PDGFRA Proteins) wild-type GIST carried mutations in one of the four subunits of the SDH complex (six patients in SDHA (show SDHA Proteins), two in SDHB (show SDHB Proteins), one in SDHC

  9. Thoracic paragangliomas are common in patients with SDHC mutations, and imaging of this area should be included in surveillance of mutation carriers.

  10. SDH deficiency may promote tumorigenesis through accumulation of succinate and inhibition of dioxygenase enzymes. Inhibition of TET activity may, in turn, alter global DNA methylation (show HELLS Proteins) and gene expression in SDH-deficient tumors.

Cow (Bovine) Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa (SDHC) interaction partners

SDHC Protein Profile

Protein Summary

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with SDHC

  • succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (SDHC)
  • succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (sdhc)
  • succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (SdhC)
  • succinate dehydrogenase complex, subunit C, integral membrane protein (Sdhc)
  • 0610010E03Rik protein
  • AI316496 protein
  • AU019277 protein
  • CYB560 protein
  • CYBL protein
  • PGL3 protein
  • QPS1 protein
  • SDH3 protein
  • SDHC protein

Protein level used designations for SDHC

succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa , ENSANGP00000017418-like protein , OXPHOS complex II cytochrome B560 subunit , succinate dehydrogenase C , succinate dehydrogenase cytochrome b560 subunit, mitochondrial , QPs-1 , QPs1 , integral membrane protein CII-3 , succinate dehydrogenase complex, subunit C , cytochrome B large subunit of complex II , integral membrane protein CII-3b , succinate dehydrgenase cytochrome b , succinate dehydrogenase 3, integral membrane subunit , succinate-ubiquinone oxidoreductase cytochrome B large subunit , succinate dehydrogenase complex subunit C

GENE ID SPECIES
478983 Canis lupus familiaris
496650 Xenopus (Silurana) tropicalis
719978 Macaca mulatta
747462 Pan troglodytes
100114948 Nasonia vitripennis
100126849 Sus scrofa
66052 Mus musculus
289217 Rattus norvegicus
6391 Homo sapiens
327696 Bos taurus
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