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Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Additionally we are shipping Sulfatase 2 Antibodies (89) and Sulfatase 2 Kits (13) and many more products for this protein.
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Sulf2 expression is almost entirely restricted to the CNS.
Our data confirmed that Sulf2 promoted breast cancer progression and regulated the expression of tumor-related genes in breast cancer.
Tumor expression of SULF2 may affect prognosis in NSCLC, while blood SULF2 levels may have a significant role in the diagnosis of this fatal disease.
SULF2 have a pro-tumorigenic effect in DU-145 and PC3 (show PCSK1 Proteins) cancer cells, suggesting an important role of this enzyme in prostatic cancer metastasis.
Results show that SULF1 (show SULF1 Proteins) or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion.
Substrate specificity of human SULF2.
SULF2 blood levels increased with age in both healthy and cirrhosis patients.SULF2 blood level was higher in cirrhosis patients than healthy individuals.
pectin induced the expression of HSulf-2 through the interaction with fibronectin, alpha5beta1 integrin, and ERK1/2
SULF2 expression in human tumor tissue and cell lines, was assessed.
Our findings define Sulf-2 as a novel positive regulator of neuroblastoma (show ARHGEF16 Proteins) pathogenicity that contributes to MYCN (show MYCN Proteins) oncogenicity.
The SULF2 single nucleotide polymorphism was reproducibly associated with lower fasting plasma triglycerides levels in obese type 2 diabetic subjects.
Sulf1 (show SULF1 Proteins) and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 (show SULF1 Proteins) and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
It is proposed that Sulf1 (show SULF1 Proteins), Sulf2 and ErbB1 (show EGFR Proteins) are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
Sulf1 (show SULF1 Proteins)/, but not Sulf2/, mice, exhibited a marked delay in healing of corneal epithelial wounds.
SULF2 regulates tissue regeneration in part via the activation of a novel WNT (show WNT2 Proteins)-GLI1 (show GLI1 Proteins)-CYCLIN D1 (show CCND1 Proteins) pathway.
Sulf1 (show SULF1 Proteins) and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.
Heparan sulfate sulfatase (show SGSH Proteins) SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma
Sulf-1 (show SULF1 Proteins) and Sulf-2 are essential regulators of GDNF (show GDNF Proteins) signaling in the SSC (show CYP11A1 Proteins) niche and direct downstream targets of Sertoli cell-specific transcriptional factor Wilm's tumor 1.
SULF2 is an unexpected suppressor of atherogenic lipoprotein clearance by hepatocytes
These results reveal that Sulf1 (show SULF1 Proteins) and Sulf2 fulfil non-redundant functions in vivo in the development and maintenance of the murine nervous system.
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005
, extracellular sulfatase Sulf-2-like
, extracellular sulfatase Sulf-2
, sulfatase FP2a
, sulfatase FP2b
, sulfatase FP2