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SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. Additionally we are shipping Symplekin Antibodies (53) and Symplekin Proteins (6) and many more products for this protein.
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Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (show CPSF3 ELISA Kits), CPSF100 (show CPSF2 ELISA Kits), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (show CPSF3 ELISA Kits) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
Data indicate rs56848936 in the gene symplekin protein (SYMPK) at 19q13.3, associated with colon cancer risk.
CPSF2 (show CPSF2 ELISA Kits) and SYMPK, are RBFOX2 (show RBM9 ELISA Kits) cofactors for both inclusion and exclusion of internal exons.
Symplekin interacts and co-localizes with both MOZ (show MYST3 ELISA Kits) and MLL (show MLL ELISA Kits) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (show HOXA9 ELISA Kits) protein level but not of Hoxa9 (show HOXA9 ELISA Kits) mRNA.
Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser (show SIGLEC1 ELISA Kits) 5 phosphatase Ssu72 (show SSU72 ELISA Kits) and a CTD Ser (show SIGLEC1 ELISA Kits) 5 phosphopeptide
Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp (show CKAP5 ELISA Kits)).
Data show that claudin-2 (show CLDN2 ELISA Kits) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (show CLDN2 ELISA Kits) down-regulation increased the transepithelial resistance and decreased cyclin D1 (show CCND1 ELISA Kits) expression and ZONAB (show CSDA ELISA Kits) nuclear localization.
symplekin has a role in HSF1 (show HSF1 ELISA Kits) modulation of Hsp70 (show HSP70 ELISA Kits) mRNA polyadenylation
The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.
The symplekin/ZONAB (show CSDA ELISA Kits) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (show RUNX1 ELISA Kits).
Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (show CPSF2 ELISA Kits) binding protein that serves as a scaffold upon which regulatory factors are assembled
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
, hepatocyte nuclear factor 3 gamma