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The protein encoded by SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Additionally we are shipping Syndecan 1 Kits (58) and Syndecan 1 Proteins (32) and many more products for this protein.
Showing 10 out of 365 products:
Mouse (Murine) Monoclonal SDC1 Primary Antibody for IHC (fro), FACS - ABIN967377
Bernfield, Kokenyesi, Kato, Hinkes, Spring, Gallo, Lose: Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. in Annual review of cell biology 1993
Show all 9 references for ABIN967377
Human Polyclonal SDC1 Primary Antibody for WB - ABIN650771
Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ... in Cell 2007
Show all 2 references for ABIN650771
Human Monoclonal SDC1 Primary Antibody for FACS - ABIN1384048
Cheriyath, Glaser, Waring, Baz, Hussein, Borden: G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. in The Journal of clinical investigation 2007
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Human Monoclonal SDC1 Primary Antibody for ICC, FACS - ABIN1724936
Karasneh, Ali, Shukla: An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread. in PLoS ONE 2011
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Human Polyclonal SDC1 Primary Antibody for EIA, WB - ABIN453562
Endo, Takino, Miyamori, Kinsen, Yoshizaki, Furukawa, Sato: Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. in The Journal of biological chemistry 2003
Show all 2 references for ABIN453562
Human Polyclonal SDC1 Primary Antibody for IF (p), IHC (p) - ABIN674769
Miyatani, Saito, Murakami, Watanabe, Kuroda, Matsunaga, Fukumoto, Osaki, Nakayama, Umekita, Ikeguchi: A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis. in Virchows Archiv : an international journal of pathology 2016
Human Monoclonal SDC1 Primary Antibody for FACS, IHC - ABIN1383809
Yang, MacLeod, Dai, Khotskaya-Sample, Shriver, Venkataraman, Sasisekharan, Naggi, Torri, Casu, Vlodavsky, Suva, Epstein, Yaccoby, Shaughnessy, Barlogie, Sanderson: The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. in Blood 2007
Human Monoclonal SDC1 Primary Antibody for FACS - ABIN1384049
Kuchen, Robbins, Sims, Sheng, Phillips, Lipsky, Ettinger: Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. in Journal of immunology (Baltimore, Md. : 1950) 2007
all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function.
We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
In this study, we provide evidence that Dlp (show DMD Antibodies) and Sdc have both overlapping and distinct functions in axon guidance and in defining accurate patterns of axonal fasciculation within the lateral CNS neuropil
Syndecan acting as a co-receptor for Slit in the Drosophila heart.
Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS.
The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR (show PTPRF Antibodies) receptor tyrosine phosphatase (show PTPRU Antibodies).
Dlp (show DMD Antibodies), which lacks chondroitin sulfate (CS)modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.
Systemic sclerosis (SSc (show CYP11A1 Antibodies)) patients with elevated serum syndecan-1 levels had higher prevalence of telangiectasia, elevated right ventricular systolic pressure and decreased diffuse capacity of the lung for carbon monoxide than those with normal levels. Therefore, soluble syndecan-1 may be related to the development of proliferative vasculopathy in SSc (show CYP11A1 Antibodies) patients.
in colorectal adenomas, the heparanase-1 (show HPSE Antibodies) does not participate in syndecan-1 degradation; the heparanase-2 (show HPSE2 Antibodies) does not stimulate syndecan-1 degradation by the action of heparanase-1 (show HPSE Antibodies), and the heparanase-2 (show HPSE2 Antibodies) may be involved in the modulation of the heparanase-1 (show HPSE Antibodies) activity.
Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19 (show RPL19 Antibodies)-IL2 (show IL2 Antibodies) immunocytokine in human melanoma xenografts.
The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients.
miR (show MLXIP Antibodies)-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation.
The results suggest that Sdc1 may modulate fibronectin (show FN1 Antibodies) fibrillogenesis and/or alter cell morphology during ECM (show MMRN1 Antibodies) production through alphavbeta3 integrin, thereby mediating ECM (show MMRN1 Antibodies) fiber alignment.
Syndecan-1 on epithelial tumor cells promotes MIF (show AMH Antibodies) binding and MIF (show AMH Antibodies)-mediated cell migration. This may represent a relevant mechanism through which MIF (show AMH Antibodies) enhances tumor cell motility and metastasis.
SULF1 (show SULF1 Antibodies) levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 (show SULF1 Antibodies) in malignant mesothelioma.
Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM.
miR (show MLXIP Antibodies)-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1.
This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis.
Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase (show GUSB Antibodies) heparanase (HPSE (show HPSE Antibodies)).
Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 (show ADAM17 Antibodies) and promotes lung epithelial tumor cell migration and lung metastasis formation.
The PPARgamma (show PPARG Antibodies) agonist rosiglitazone rescues Sdc1-/- intradermal adipose tissue, placing PPARgamma (show PPARG Antibodies) downstream of Sdc1 in triggering adipocyte differentiation
Specific structural motifs in syndecan-1 HS promote Staphylococcus aureus corneal infection by inhibiting neutrophil CRAMP.
Syndecan-1 is expressed in the parietal peritoneum microvasculature but does not regulate leukocyte recruitment and is not necessary for the presentation of the chemokine (show CCL1 Antibodies) MIP-2 (show CXCL2 Antibodies) in this tissue.
These results demonstrate that defective motility in Sdc-1(-/-) macrophages promotes a persistent inflammatory state with relevance to the pathogenesis of atherosclerosis.
Sdc1 affects arteriogenesis in response to hindlimb ischemia and is required in the local tissue environment for normal arteriogenesis.
Syndecan-1 promotes vascular smooth muscle cell differentiation and quiescence.
Heparan sulfate is involved in both centralized and decentralized glycocalyx-mediated mechanotransduction, with GPC1 (show GPC1 Antibodies) acting as a centralized agent and SDC1 functioning in decentralized mechanotransmission. GPC1 (show GPC1 Antibodies) mediates NOS3 (show NOS3 Antibodies) activation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
, syndecan 1
, CD138 antigen
, heparan sulfate proteoglycan fibroblast growth factor receptor
, syndecan proteoglycan 1