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Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. Additionally we are shipping STXBP5 Antibodies (6) and many more products for this protein.
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Using CRISPR/Cas9 genome editing, identified a human nonsynonymous SNP rs1039084 in the STXBP5 locus as a causal variant for a decreased thrombotic phenotype.
Genetic variations in STXBP5 and CLEC4M (show CLEC4M Proteins) are associated with VWF (show VWF Proteins) level variation in type 1, but not in type 2 von Willebrand disease.
STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion
STXBP5 inhibits endothelial exocytosis and promotes platelet secretion
Identify 3 loci associated with circulating tPA (show PLAT Proteins) levels, the PLAT (show PLAT Proteins) region, STXBP5, and STX2 (show STX2 Proteins). Functional studies implicate a novel role for STXBP5 and STX2 (show STX2 Proteins) in regulating tPA (show PLAT Proteins) release.
Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.
Genetic variation in STXBP5 gene is associated with venous thrombosis.
multiple domains outside the R-SNARE (show YKT6 Proteins) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion
Genetic variability in STXBP5 and STX2 (show STX2 Proteins) affects both VWF (show VWF Proteins) concentration and activity in young individuals with premature arterial thrombosis.
Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed.
Mouse Embryonic Stem (mES (show PTCH1 Proteins)) cells self-differentiated into arginine vasopressin (AVP (show AVP Proteins)) neurons (mES (show PTCH1 Proteins)-AVP (show AVP Proteins)) that expressed tomosyn and two transmembrane SNARE (show VTI1B Proteins) proteins, including SNAP25 (show SNAP25 Proteins) and syntaxin1 (show STX1A Proteins). Tomosyn negatively regulates arginine vasopressin (show AVP Proteins) secretion in embryonic stem cell-derived neurons.
PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (show SUMO2 Proteins)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.
regulates SNARE (show VTI1B Proteins) complex formation and synaptic vesicle fusion. (review)
Interacts with SNAP23 (show SNAP23 Proteins) and Syntaxin4 (show STX4 Proteins) and plays a role in Insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) translocacion.
The interaction between syntaxin4 (show STX4 Proteins) and Munc18c (show STXBP3 Proteins) in adipocytes results in enhancement of insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) externalization.
In the pancreatic beta-cell, tomosyn negatively regulates insulin (show INS Proteins) exocytosis.
Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (show INS Proteins) secretagogues.
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.
lethal(2) giant larvae protein homolog 3
, putative protein product of Nbla04300
, syntaxin-binding protein 5
, tomosyn 1